Korean J Hematol.  1997 Nov;32(3):470-475.

An Unusual Case of Sweet's Syndrome Associated with Myelodysplastic Syndrome

• Hahn JS
• Lee JH
• Choi SW
• Min YH
• Ko YW
• Lee KH
• Lee KK

Abstract

Sweet's syndrome, initially described in 1964 as acute febrile neutrophilic dermatosis by Sweet, is characterized by five cardinal feature: fever; neutrophilia; abrupt appearance of erythematous, painful, cutaneous plaque, primarily located on the upper extremities, head and neck; a dermal infiltrate of mature neutrophils; and a rapid response to steroid therapy. More than 500 cases of Sweet's syndrome have been documented since original description of Sweet, of which, approximately, 15~20 percent of published cases occurred in patient with hematologic malignancy. The authors describe an unusual case of Sweet's syndrome in a man, who affected with myelodysplastic syndrome (RAEB). A 56-year-old male patient admitted to Yonsei University, Medical Center because of sustained fever and cellulitis of right lower leg. With anemia and thrombocytopenia, the bone marrow study revealed myelodysplastic syndrome (RAEB). On 4th hospital day, with the development of pneumonia, he was treated with mechanical ventilation and broad spectrum of antibiotics. Although the treatment of pneumonia was successful, erythematous nodules, showing Koebner phenomenon and strong positive pathergy reaction, was appeared on the whole body (21st hospital day). Skin biopsy was taken. Under the diagnosis of Sweet's syndrome associated with myelodysplastic syndrome (RAEB), oral prednisolone 60mg/day was prescribed. The cuteneous lesions were regressed, but the brownish pigmentation was remained, till the patient discharged.

Keyword

Myelodysplastic syndrome (RAEB); Sweet's syndrome; Koebner phenomenon; Pathergy reaction

MeSH Terms

Anemia
Anti-Bacterial Agents
Biopsy
Bone Marrow
Cellulitis
Diagnosis
Fever
Head
Hematologic Neoplasms
Humans
Leg
Male
Middle Aged
Myelodysplastic Syndromes*
Neck
Neutrophils
Pigmentation
Pneumonia
Prednisolone
Respiration, Artificial
Skin
Sweet Syndrome*
Thrombocytopenia
Upper Extremity
Anti-Bacterial Agents
Prednisolone