Korean J Hematol.
1997 Nov;32(3):433-439.
A Case of Leukemic Transformation in Essential Thrombocythemia Treated with Hydroxyurea
- Affiliations
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- 1Department of Internal Medicine, Maryknoll Hospital, Pusan, Korea.
- 2Department of Clinical Pathology, Maryknoll Hospital, Pusan, Korea.
Abstract
- Essential thrombocythemia is a myeloproliferative disorder, characterized by marked thrombocytosis and marrow megakaryocytic hyperplasia. Although the major causes of morbidity and mortality are bleeding and thromboembolic events, the long-term prognosis is favorable and leukemic transformation is rare. We report a case of acute leukemia following treatment of Philadelphia chromosome-negative essential thrombocythemia with hydroxyurea for 4 years with a brief review of literature.
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