The Effects of Midazolam on Propofol-Induced Involuntary Movement, Pain on Injection and Maintenance Dose

Cho, Sang Yoon; Kim, Kyoung Hun; Shin, Woo Jong; Yeom, Jong Hoon; Kim, Yong Chul; Lee, Dong Ho

Abstract

BACKGROUND: This study examined the effects of midazolam on the propofol-induced involuntary movements, pain on injection, the maintenance dose of propofol, and recovery characteristics.
METHODS
In a double-blind, randomized study, 30 children (2 8 yr of age, ASA physical status I or II) undergoing short duration of ENT procedures received midazolam 0.06 mg/kg (Group M) or an equal volume of placebo (Group P) intravenously 3 min before the injection of propofol. At induction of anesthesia an independent anesthesiologist graded the incidence, severity of involuntary movements, and pain on injection.
RESULTS
Both groups were similar in age, sex, weight, propofol dose, duration of surgery and anesthesia. Incidence of involuntary movements showed no significant difference between two groups. But, there were significant difference in severity between two groups (P < 0.05). There was significant decrease in pain on injection in group M than group P and no significant differences in open eyes on command, time to extubation and time to discharge.
CONCLUSION
Our result demonstrated that midazolam 60 microgram/kg compared with placebo did not reduce the incidence of involuntary movement, but reduced the severity of involuntary movement without delayed recovery. And there was significant reduction of pain on injection in midazolam 60 microgram/kg administration.