Korean Circ J.  1993 Aug;23(4):597-602. 10.4070/kcj.1993.23.4.597.

Antihypertensive Effect of Ramipril in Patients with Essential Hypertension

• Song JS
• Kim YS
• Cheong HJ
• Kang HS
• Choue CW
• Kim KS
• Kim MS
• Bae JH

• KMID: 2029374
• DOI: http://doi.org/10.4070/kcj.1993.23.4.597

Abstract

BACKGROUND
Angiotensin converting enzyme(ACE) inhibition as a means of controlling blood pressure began in the 1970s. This increasing knowledge of ACE inhibitors has resulted in their being used with confidence in a antihyertensive therapy, combining high efficacy with very low levels of side effects. METHOD: In this study, the antihyertensive effect of ramipril was assessed in 28 patients(9 males and 19 females with mean age of 52 years)with mild-to-moderate hypertension. After a placebo run-in phase, patients received ramipril as monotherapy in a dose 2.5 to 5 mg daily for 6 weeks. RESULTS: 1) At the end of 6 weeks, ramipril induced clinically significant reduction in supine(30.1mmHg in systole, 17mmHg in diastole) and sitting(33.4mmHg in systole, 18.5mmHg in diatole)blood pressure. 2) The heart rate was similar after 6 weeks. 3) The most frequent side effect was dry cough in 6 patients(5.6%) followed by dizziness. CONCLUSION: This study indicate that ramipril is effective in the treatment of mild to moderate essential hypertension.

Keyword

Ramipril; Essential Hypertension; ACE inhibitor

MeSH Terms

Angiotensin-Converting Enzyme Inhibitors
Angiotensins
Blood Pressure
Cough
Dizziness
Female
Heart Rate
Humans
Hypertension*
Male
Ramipril*
Systole
Angiotensin-Converting Enzyme Inhibitors
Angiotensins
Ramipril