J Korean Rheum Assoc.  1995 Jan;2(1):52-59.

Clinical Analysis Of Adult Onset Still's Disease: 22 Cases In Korea

• Lee EB
• Song YW

Abstract

OBJECTIVE
To investigate the clinical manifestations of adult onset Still's disease in Korea.
METHODS
22 patients who were diagnosed at Seoul National University Hospital during 10 years from March, 1984 to June, 1994 were reviewed.
RESULTS
Age of onset was evenly distributed between 16 and 45 years in most of the patients. Fever and arthralgia were present in all cases. Arthritis and skin rash were developed in 91% and 77% of the patients respectively. Laboratory tests showed accelerated ESR in 95~o, increased serum ferritin in 79%, leukocytosis in 68%, anemia in 32%, hypoalbuminemia in 32%, and abnormal liver function test in 36% of the patients. Commonly affected joints were knees, wrists, proximal interphalangeal joints, ankles, elbows and shoulders in order. Bone marrow biopsy in 7, lymph node biopy in 2 cases revealed reactive hyperplasia. Nonsteroidal anti-inflammatory drugs (NSAID) were effective in 73% of the patients, corticosteroid with or without NSAID in 50% of the patients. Toxic hepatitis was developed in 2, acute renal failure in 1 and drug rash in 1 case during NSAID treatment, which resolved after discontinuance or switching to another NSAID.
CONCLUSIONS
The clinical manifestations of AOSD in Korea generally resemble those previously reported in other countries except that lymphadenopathy, splenomegaly, joint deformity, pleurisy, leukocytosis and anemia were significantly less frequent in our cases.

Keyword

Adult Inset Still's Disease; Fever; Skin rash; Arthritis; Leukocytosis

MeSH Terms

Acute Kidney Injury
Adult*
Age of Onset
Anemia
Ankle
Arthralgia
Arthritis
Biopsy
Bone Marrow
Congenital Abnormalities
Drug-Induced Liver Injury
Elbow
Exanthema
Ferritins
Fever
Humans
Hyperplasia
Hypoalbuminemia
Joints
Knee
Korea*
Leukocytosis
Liver Function Tests
Lymph Nodes
Lymphatic Diseases
Pleurisy
Seoul
Shoulder
Splenomegaly
Still's Disease, Adult-Onset*
Wrist
Ferritins