Korean J Pediatr Gastroenterol Nutr.  2011 Mar;14(1):1-25. 10.5223/kjpgn.2011.14.1.1.

Pediatric Inflammatory Bowel Disease (IBD): Phenotypic, Genetic and Therapeutic Differences between Early-Onset and Adult-Onset IBD

Affiliations
  • 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. jkseo@snu.ac.kr

Abstract

Inflammatory bowel disease (IBD) develops during childhood or adolescence in approximately 25% of patients with IBD. Recent studies on pediatric IBD have revealed that early-onset IBD has distinct phenotype differences compared to adult onset IBD. Pediatric early-onset IBD differs in many aspects including disease type, location of the lesions, disease behavior, gender preponderance and genetically attributable risks. This review examines the currently published data on the clinical, epidemiological and genetic differences between early-onset and adult-onset IBD. And finally, therapeutic considerations in the management of pediatric-onset IBD are also discussed.

Keyword

Pediatric inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Early onset

MeSH Terms

Adolescent
Adult
Colitis, Ulcerative
Crohn Disease
Humans
Inflammatory Bowel Diseases
Phenotype
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