Korean J Dermatol.  2007 Jan;45(1):63-68.

Two Cases of Pyoderma Gangrenosum Associated with Crohn's Disease

• Jang HC
• Park G
• Kim HJ
• Lee SW
• Chung H

Abstract

Pyoderma gangrenosum has been described in association with a wide variety of disorders, including Crohn's disease, ulcerative colitis, myeloproliferative disease, monoclonal gammopathy, and Behcet's disease. Herein, we report two cases of pyoderma gangrenosum associated with Crohn's disease. The first case was a 24-year-old female who presented with multiple, necrotizing ulcers on the scalp, which is a rarely affected site. The other case was a 30-year-old female who presented with erythema nodosum on the lower leg initially, and subsequent rapidly-progressive ulcerating lesions then developed at the previous biopsy and intravenous injection sites. In both cases, the colonoscopic findings were consistent with Crohn's disease. The lesions improved with a combined therapy of systemic steroids, sulfa drugs and topical 0.03% tacrolimus ointment.

Keyword

Crohn's disease; Pyoderma gangrenosum

MeSH Terms

Adult
Biopsy
Colitis, Ulcerative
Crohn Disease*
Erythema Nodosum
Female
Humans
Injections, Intravenous
Leg
Paraproteinemias
Pyoderma Gangrenosum*
Pyoderma*
Scalp
Steroids
Tacrolimus
Ulcer
Young Adult
Steroids
Tacrolimus