J Korean Fract Soc.  2003 Jul;16(3):416-422. 10.12671/jksf.2003.16.3.416.

The Effect of Platelet-Rich Plasma (PRP) on the Healing of Allograft for the Treatment of Segmental Bone Defect of the Ulna in Rabbits

• Song JH
• Jeong J
• Kang YK
• Lee HY
• Son MI
• Seo SI

• KMID: 1999368
• DOI: http://doi.org/10.12671/jksf.2003.16.3.416

Abstract

PURPOSE: The purpose of this study was to evaluate the effect of Platelet-Rich Plasma (PRP) on the healing of the allograft for the treatment of the segmental bone defect of the ulna in Rabbits.
MATERIALS AND METHODS
About 2 cm-sized segmental bone defects were created on both ulna of twenty rabbits. The rabbits were divided into two groups, even and odd number group after numbering them from 1 to 20. The segmental bone from the odd numbered animal was transplanted to the even numbered animal, and the even numbered to the odd numbered. The left side of the ulna of the animal is grafted with a segmental allograft only. The right side of the ulna was grafted with a segmental allograft and 0.7 cc of PRP. Radiographs obtained at 0, 4, 8, and 12 weeks postoperatively were graded for radiologic union.
RESULTS
The use of the combination of PRP and segmental allograft demonstrated improved healing on radiolographic study compared with that demonstrated after use of allogrft alone.
CONCLUSION
The results of the study suggests that the use of the combination of PRP and segmental allograft can be considered as an alternative method to manage the segmental defect of the long bone.

Keyword

PRP (Platelet-Rich Plasma); Allograft; Segmental bone defect; Bone union

MeSH Terms

Allografts*
Animals
Platelet-Rich Plasma*
Rabbits*
Transplants
Ulna*