J Korean Bone Joint Tumor Soc.  2010 Jun;16(1):8-13. 10.5292/jkbjts.2010.16.1.8.

The Effect of Platelet-Rich Plasma on Allograft Transplantation after Curettage in Benign Bone Tumor

Affiliations
  • 1Department of Orthopaedic Surgery, Kosin University Gospel Hospital, Busan, Korea. jdkim207@hanmail.net

Abstract

PURPOSE
This study was performed to evaluate the efficiency of Platelet-rich plasma (PRP) for acceleration of bone healing process on allograft transplantation after curettage in benign bone tumor.
MATERIALS AND METHODS
From December 2007 to February 2009, twenty-one patients who had benign bone tumor and underwent allograft transplantation after curettage were evaluated. Mean follow-up period was 14.6 months (range, 12-26 months). We compared with 13 cases of PRP group and 8 cases of non-PRP group in terms of size of lesion, bone resorption, amount of applied PRP and complications. The mean age at surgery was 23.6 years (range, 4-73 years). The most common diagnosis was simple bone cyst (7) followed by enchondroma (4), giant cell tumor (3), undifferentiated benign bone tumor (3) and so on.
RESULTS
The mean size of lesion was 33.5 cm3 (range, 2.3-181.9 cm3) (29.4 cm3 in PRP group and 40.2 cm3 in non-PRP group). The mean volume of injected PRP was 7.4 cc (range, 3-12 cc). Bone union started at 3.0 months (range, 1.5-5.8 months) in PRP group and 5.3 months (range, 4-8 months) in non-PRP group. Three cases for each group were excluded due to recurrence and pathologic fracture. One patient had febrile episode 3 weeks later after surgery which subsided with antibiotics.
CONCLUSION
The PRP could accelerate bone union in allograft transplantation after curettage of benign bone tumor. Furthermore, we expect that PRP can accelerate bone union in fracture or non-union.

Keyword

benign bone tumor; allograft transplantation; platelet-rich plasma (PRP)

MeSH Terms

Acceleration
Anti-Bacterial Agents
Bone Cysts
Bone Resorption
Chondroma
Curettage
Follow-Up Studies
Fractures, Spontaneous
Giant Cell Tumors
Humans
Platelet-Rich Plasma
Recurrence
Transplantation, Homologous
Transplants
Anti-Bacterial Agents

Figure

  • Figure 1. Simple bone cyst of the proximal humerus of a 6-year-old patient. (A) The preoperative humerus AP radiograph. (B) PRP was applied after curettage and bone allograft transplantation. (C) Partial resorption of allograft and new trabeculae formation were observed 2.5 months later after operation.


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