Changes in t-PA and PAI-1 levels after exercise in patients with diabetes mellitus: A sex and age-matched control study

Choi, Jung Hye; Kim, Sun Gil; Lee, Woong Soo; Kim, Tae Wha; Kim, Tae Young; Shin, Jin Ho; Lee, Jae Ung; Kim, Kyung Soo; Kim, Jeong Hyun; Lim, Heon Kim; Lee, Bang Hun; Lee, Chung Kyun

Abstract

OBJECTIVES
Plasma fibrinolytic activity is determined by the balance between plasmonogen activators and their inhibitors. The aim of this study was to compare the fibrinolytic activity before and after exercise of the type 2 diabetic patients with control group.
METHODS
We measured plasma tissue-plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) antigen before and after standardized treadmill exercise in 21 type 2 diabetic patients (14 men, 11 women, ages 46.2+/-5.6 years) and 21 sex and age- matched control group (10 men, 11 women, ages 48.6+/-5.4 years).
RESULTS
1) Post exercise t-PA antigen increased in both diabetic group (from 7.36+/-3.89 to 10.62+/-4.81 ng/ml, p<0.05) and control group (from 8.30+/-3.99 to 10.99+/-5.52 ng/ml, p<0.05). But the rise in t-PA antigen with exercise was similar in both group. 2) Both base line and post exercise PAI-1 antigen levels were similar between the diabetic group (from 29.46+/-10.35 to 31.48+/-12.94 ng/ml, p>0.05) and control group (from 30.04+/-10.40 ng/ml to 31.06+/-10.88 ng/ml, p>0.05). 3) In diabetic group, significant correlations between base line PAI-1 antigen levels and serum triglyceride levels were observed. And post exercise PAI-1 antigen levels were correlated with systolic blood pressure.
CONCLUSION
The results show that plasma t-PA antigen level is increased after vigorous exercise in patients with type 2 diabetes mellitus and plasma PAI-1 antigen level is not changed. The increment of plasma t-PA level is not different with healthy subjects.