J Cardiovasc Ultrasound.  2011 Jun;19(2):62-66. 10.4250/jcu.2011.19.2.62.

Arterial-Cardiac Interaction: The Concept and Implications

  • 1Cardiology Division, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea. cysprs@yuhs.ac


Vascular stiffening of the large arteries is a common feature of human aging. Increased aortic stiffness with age may contribute to pathological changes in the left ventricle and this can induce ventricular stiffening. Vascular-ventricular stiffening combined with abnormal arterial-cardiac interaction is considered an important pathophysiology of heart failure with a preserved ejection fraction. Here, I briefly review the concept and implications of arterial-cardiac interaction and this will pave the way to understanding and controlling heart failure with a preserved ejection fraction, which is more prevalent in the elderly.


Aortic stiffness; Left ventricle; Heart failure

MeSH Terms

Heart Failure
Heart Ventricles
Vascular Stiffness


  • Fig. 1 Indices and surrogates of arterial stiffness. PWV: pulse wave velocity, AIx: augmentation index, BP: blood pressure.

  • Fig. 2 Pathophysiological pathways: Relation of arterial stiffness to diastolic dysfunction in hypertensive patients.16) BP: blood pressure, LV: left ventricular.

  • Fig. 3 Schematic diagram of the pressure-volume loop for the left ventricle.

  • Fig. 4 Relationship between effective arterial elastance (Ea) and ventricular systolic elastance (Ees) in young (A) versus old subjects (B).24) A: In young subject. B: A matched increase in arterial and ventricular stiffness in elderly subjects.

  • Fig. 5 Dynamic changes of ventricular-vascular coupling under stress caused by exercise (A)27) and volume overload (B).24)

Cited by  1 articles

Heart Failure with Preserved Ejection Fraction: the Major Unmet Need in Cardiology
Chi Young Shim
Korean Circ J. 2020;50(12):1051-1061.    doi: 10.4070/kcj.2020.0338.


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