J Bone Metab.  2012 Nov;19(2):87-93. 10.11005/jbm.2012.19.2.87.

Serum Bisphenol A Concentration in Postmenopausal Women with Osteoporosis

• Kim DH
• Oh CH
• Hwang YC
• Jeong IK
• Ahn KJ
• Chung HY
• Chang JS

• KMID: 1975981
• DOI: http://doi.org/10.11005/jbm.2012.19.2.87

Abstract

OBJECTIVES
Bishphenol A (BPA) is a representative endocrine disruptor and is also known as a xenoestrogen. The objective of the present study is to investigate how many patients are exposed to BPA and to analyze the relationships between serum BPA concentration, bone mineral density (BMD) and biochemical bone markers in postmenopausal women with osteoporosis.
METHODS
Total 51 patients were enrolled for measuring BPA and clinical variables including BMD and bone markers. The relationship between BPA and clinical variables were analyzed by the Pearson's correlation test and the Kruskal-Wallis test. Serum BPA concentration was measured by enzyme linked immunosorbent assay (ELISA).
RESULTS
BPA was detected in all samples. The mean BPA concentration was 1.44 +/- 0.52 ng/mL. There was no statistically significant correlation between BPA and clinical variables.
CONCLUSION
There was no statistical significance between serum BPA concentration and clinical variables related to bone metabolism. To clarify the effect of BPA on bone metabolism, further large scaled and high risk group investigation may be needed.

Keyword

Bisphenol A; Bone markers; Bone mineral density; Osteoporosis

MeSH Terms

Benzhydryl Compounds
Bone Density
Enzyme-Linked Immunosorbent Assay
Female
Humans
Osteoporosis
Phenols
Benzhydryl Compounds
Phenols

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