J Korean Assoc Oral Maxillofac Surg.
2002 Feb;28(1):42-45.
Bone Formation By Human Alveolar Bone Cells
- Affiliations
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- 1Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University, Korea.
- 2Department of Dentistry, Asan Kangnung Hospital, Kangnung, Korea.
- 3Department of Orthopedics, Wonju College of Medicine, Yonsei University, Korea.
Abstract
- Cultures of primary human alveolar bone-derived cells were established from alveolar bone chips obtained from normal individuals undergoing tooth extraction. These cells were expanded in vitro until passage 3 and used for the in vivo assays. Cells were loaded into transplantation vehicles, and transplanted subcutaneously into immunodeficient mice to study the capacities of human alveolar bone-derived cells to form bone in vivo. Transplants were harvested 12 weeks after transplantation and evaluated histologically. Of 10 human alveolar bone-derived cell transplants, two formed a bone-like tissue that featured osteocytes and mineral. Eight of the ten formed no osseous tissue. These results show that cells from normal human alveolar bone are capable of forming bone-like tissue when transplanted into immunodeficient mice.
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