J Korean Ophthalmol Soc.  1997 Jul;38(7):1194-1202.

Experimental Branch Retinal Vein Occlusion in Albino Rats

Affiliations
  • 1Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
  • 2Department of Ophthalmology, Samsung Medical CenterChangs Eye Clinic, Incheon, Korea.

Abstract

The retinal vein occlusion is one of the most common retinal diseases, and the establishment of animal model in rats will be a great help for further study. We occluded branch retinal veins with rose bengal dye injection followed by argon-green laser photocoagulation in albino rats. Retinal vein occlusion was maintained over 1 day in 35 eyes out of 47, maximally over 5 days. Retinal tissue damage was confined to the photocoagulated areas in most eyes and the loss of ganglion cells began when the occlusion persisted over 1 day. If the reproducibility is further increased, this will be a good animal model of retinal vein occlusion in albino rats.

Keyword

Retinal vein occlusion; Animal model; Rose bengal; Laser Laser photocoagulation

MeSH Terms

Animals
Ganglion Cysts
Light Coagulation
Models, Animal
Rats*
Retinal Diseases
Retinal Vein Occlusion*
Retinal Vein*
Retinaldehyde*
Rose Bengal
Retinaldehyde
Rose Bengal
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