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Cranial and Spinal Window Preparation for in vivo Optical Neuroimaging in Rodents and Related Experimental Techniques

Yeon C, Im JM, Kim M, Kim YR, Chung E

  • KMID: 2531117
  • Exp Neurobiol.
  • 2022 Jun;31(3):131-146.
  • doi: 10.5607/en22015
Optical neuroimaging provides an effective neuroscience tool for multi-scale investigation of the neural structures and functions, ranging from molecular, cellular activities to the inter-regional connectivity assessment. Amongst experimental preparations, the...
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Evaluation of host and bacterial gene modulation during Lawsonia intracellularis infection in immunocompetent C57BL/6 mouse model

Kirthika P, Park S, Jawalagatti V, Lee JH

Background: Proliferative enteritis caused by Lawsonia intracellularis undermines the economic stability of the swine industry worldwide. The development of cost-effective animal models to study the pathophysiology of the disease will...
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Autism-Like Behavioral Phenotypes in Mice Treated with Systemic N-Methyl-D-Aspartate

Jym Adil K, Gonzales EL, Remonde CG, Boo KJ, Jeon SJ, Shin CY

Autism spectrum disorder (ASD) having core characteristics of social interaction problems and repetitive behaviors and interests affects individuals at varying degrees and comorbidities, making it difficult to determine the precise...
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Feasibility of non-invasive recording of somatosensory evoked potential in pigs

Hoareau GL, Peters A, Hilgart D, Iversen M, Clark G, Zabriskie M, Rieke V, Floyd C, Shah L

Background: Non-invasive measurement of somatosensory-evoked potentials (SEP) in a large animal model is important to translational cognitive research. We sought to develop a methodology for neurophysiological recording via a transcranial...
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The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans

Bailone RL, Fukushima HCS, Aguiar LKd, Borra RC

Zebrafish is considered an unprecedented animal model in drug discovery. A review of the literature presents highlights and elucidates the biological effects of chemical components found in Cannabis sativa. Particular...
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Disease predictability review using common biomarkers appearing in diabetic nephropathy and neurodegeneration of experimental animals

Yi SS

It is recently known that the kidney and brain have a very rich distribution of blood vessels, and the histological structures of micro-vessels are very similar. Therefore, a number of...
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Early response evaluation of doxorubicin-nanoparticle-microbubble therapy in orthotopic hepatocellular carcinoma rat model using contrast-enhanced ultrasound and intravoxel incoherent motion-diffusion MRI

Yang HK, Kim JH, Lee HJ, Moon H, Ryu H, Han JK

Purpose: This study aimed to apply doxorubicin-loaded nanoparticle microbubble (Dox-NP-MB) therapy in an orthotopic rat model of hepatocellular carcinoma (HCC) and investigate the utility of contrast-enhanced ultrasound (CEUS) and intravoxel...
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Validation of the Thyrotoxicosis-associated Insomnia Model Induced by Thyroxine through Sympathetic Stimulation: Face, Construct and Predictive Perspectives

Ai Z, He H, Wang T, Chen L, Huang C, Chen C, Xu P, Zhu G, Yang M, Song Y, Su D

  • KMID: 2524036
  • Exp Neurobiol.
  • 2021 Dec;30(6):387-400.
  • doi: 10.5607/en21023
Insomnia has become a common central nervous system disease. At present, the pathogenesis of insomnia is not clear. Animal models can help us understand the pathogenesis of the disease and...
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Circulating Tumor Cell Detection in Lung Cancer Animal Model

Chong Y, Jung YC, Hwang E, Cho HJ, Kang MW, Na MH

Background: Metastasis and recurrence of primary cancer are the main causes of cancer mortality. Disseminated tumor cells refer to cancer cells that cause metastasis from primary cancer to other organs....
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Ventilator-induced lung-injury in mouse models: Is there a trap?

Joelsson JP, Ingthorsson S, Kricker J, Gudjonsson T, Karason S

Ventilator-induced lung injury (VILI) is a serious acute injury to the lung tissue that can develop during mechanical ventilation of patients. Due to the mechanical strain of ventilation, damage can...
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Alteration in Cngb1 Expression upon Maternal Immune Activation in a Mouse Model and Its Possible Association with Schizophrenia Susceptibility

Lee H, Kang SW, Jeong H, Kwon JT, Kim YO, Kim HJ

Objective: The cyclic nucleotide-gated channel (Cng) regulates synaptic efficacy in brain neurons by modulating Ca2+ levels in response to changes in cyclic nucleotide concentrations. This study investigated whether the expression...
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Characterization of Ferric Chloride-Induced Arterial Thrombosis Model of Mice and the Role of Red Blood Cells in Thrombosis Acceleration

Shim Y, Kwon I, Park Y, Lee HW, Kim J, Kim YD, Nam HS, Park S, Heo JH

Purpose: The ferric chloride (FeCl3)-induced thrombosis model is widely used for thrombosis research. However, it lacks standardization with uncertainty in the exact mechanism of thrombosis. This study aimed to characterize...
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The Restorative Effect of Gallic Acid on the Experimental Sciatic Nerve Damage Model

Gurkan G, Erdogan MA, Yigitturk G, Erbas O

Objective : Peripheral nerve injuries occur mostly as a result of mechanical trauma. Due to the microvascular deterioration in peripheral nerve damage, it becomes challenging to remove free oxygen radicals....
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Experimental animal models for diabetes and its related complications—a review

Kottaisamy CPD, Raj DS, Kumar VP, Sankaran U

Diabetes mellitus, a very common and multifaceted metabolic disorder is considered as one of the fastest growing public health problems in the world. It is characterized by hyperglycemia, a condition...
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Establishment of particulate matterinduced lung injury model in mouse

Park SY, An KS, Lee B, Kang JH, Jung HJ, Kim MW, Ryu HY, Shim KS, Nam KT, Yoon YS, Oh SH

Background: Particulate matter (PM) is one of the principal causes of human respiratory disabilities resulting from air pollution. Animal models have been applied to discover preventive and therapeutic drugs for...
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Validation of the Osteomyelitis Induced by Methicillin-Resistant Staphylococcus aureus (MRSA) on Rat Model with Calvaria Defect

Choi YS, Ham DS, Lim JY, Lee YK

Background: Osteomyelitis resulting from bacterial strains, such as methicillin-resistant Staphylococcus aureus (MRSA) that are resistant to multiple drugs, brings further clinical challenges. There is currently no model of osteomyelitis induced by...
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Effect of Rutin on Diabetic Auditory Neuropathy in an Experimental Rat Model

Doostkam A, Mirkhani H, Iravani K, Karbalay-Doust S, Zarei K

Objectives. Diabetic auditory neuropathy is a common complication of diabetes mellitus that has a major impact on patients’ quality of life. In this study, we assessed the efficacy of rutin...
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Freeze-dried bovine amniotic membrane as a cell delivery scaffold in a porcine model of radiation-induced chronic wounds

Oh D, Son D, Kim J, Kwon SY

Background Locoregional stem cell delivery is very important for increasing the efficiency of cell therapy. Amnisite BA (Amnisite) is a freeze-dried amniotic membrane harvested from bovine placenta. The objective of...
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Dedicated Cold Snare vs. Traditional Snare for Polypectomy of Diminutive and Small Lesions in a Porcine Model: A Research Group for Endoscopic Instruments and Stents (REIS) Study

Lee HH, Lee BI, Kim JW, Lim H, Lee SH, Cho JH, Jung Y, Kim KO, Kim CG, Lee KM, Park JJ, Choi MG, Chun HJ, Kim HG

Background/Aims: The aim of this in vivo animal study was to evaluate the effectiveness and safety of dedicated cold snare (DCS) compared with those of traditional snare (TS) for cold...
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Experimental Animal Models of Coronavirus Infections: Strengths and Limitations

Casel MAB, Rollon RG, Choi YK

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the emergence of SARS-CoV-2 in the human population in late 2019, it has spread on...
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