J Korean Pain Soc.
2002 Jun;15(1):19-25.
Effect of Serotonergic Receptors on the Antinociception of Intrathecal Gabapentin in the Formalin Test of Rats
- Affiliations
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- 1Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University, Gwangju, Korea. mhyoon@chonnam.ac.kr
Abstract
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BACKGROUND: Spinal gabapentin actively encounters tissue-injury nociception. Serotonin is involved in the modulation of nociceptive transmission at the spinal level. Gabapentin increases the blood serotonin level. This study was designed to examine the role of spinal serotonergic receptors on the action of intrathecal gabapentin in rats.
METHODS
Intrathecal catheters were inserted into the lumbar enlargement. For nociceptive test,50micro of 5% formalin was subcutaneously injected into the hind paw. The effects of intrathecal gabapentin on the formalin stimulation and of respective serotonin receptor antagonist on the action of gabapentin were examined.
RESULTS
Intrathecal gabapentin attenuated the flinching response during phase 2, but not during phase 1, of the formalin test. None of the serotonin receptor antagonists (1, 1A, 1B, 1D, 2, 2C, 3, 4) affected the antinociceptive effect of gabapentin.
CONCLUSIONS
These results suggest that spinal serotonergic receptors are not directly involved in the antinociceptive action of intrathecal gabapentin.
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