J Korean Med Sci.  2004 Aug;19(4):581-585. 10.3346/jkms.2004.19.4.581.

Interaction between Intrathecal Gabapentin and Adenosine in the Formalin Test of Rats

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, Gwangju, Korea. mhyoon@chonnam.ac.kr

Abstract

Spinal gabapentin and adenosine have been known to display an antinociceptive effect. We evaluated the nature of the interaction between gabapentin and adenosine in formalin-induced nociception at the spinal level. Male Sprague-Dawley rats were prepared for intrathecal catheterization. Pain was evoked by injection of formalin solution (5%, 50 microliter) into the hindpaw. After examination of the effects of gabapentin and adenosine, the resulting interaction was investigated with isobolographic and fractional analyses. Neither gabapentin nor adenosine affected motor function. Gabapentin or adenosine decreased the sum of the number of flinches during phase 2, but not during phase 1 in the formalin test. Isobolographic analysis, in phase 2, revealed an additive interaction between gabapentin and adenosine. Taken together, intrathecal gabapentin and adenosine attenuated the facilitated state and interacted additively with each other.

Keyword

Pain Measurement; Antinociception; Adenosine; Gabapentin; Drug Interactions; Injections, Spinal

MeSH Terms

*Adenosine/administration & dosage/metabolism/therapeutic use
*Amines/administration & dosage/metabolism/therapeutic use
*Analgesics/administration & dosage/metabolism/therapeutic use
Animals
*Cyclohexanecarboxylic Acids/administration & Dose-Response Relationship, Drug
Formaldehyde/*toxicity
Injections, Spinal
Male
Motor Activity/physiology
Pain Measurement
Rats
Rats, Sprague-Dawley
Research Support, Non-U.S. Gov't
*gamma-Aminobutyric Acid/administration & dosage/metabolism/therapeutic
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