J Korean Pain Soc.
1994 Nov;7(2):282-286.
Two Cases Report of Epidural Clonidine Analgesia in Cancer Patient and in Patient Tolerant to Opioids
- Affiliations
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- 1Department of Anesthesiology, College of Medicine, Hallym University, Kangwon, Korea.
Abstract
- The central antihypertensive agent clonidine is an a2,-adrenergic agonist that possesses painrelieving properties. It has been administered epidurally in the treatment of cancer pain and for postoperative analgesia. 1) Case l, 62-year-old woman who suffered from neurogenic pain syndrome due to metastatic squamous cell carcinoma of spinal canal was treated. 2) Case 2, 51-year-old woman undergoing lower aMominal surgery, epidurally administered morphine did not produced postoperative analgesia. In these cases, continuous epidural administeration of clonidine (200ug/day) and 0.3% bupivacaine (12 ml/day) produce high quality pain relief. These results suggest that antinociceptive effect of epidural clonidine is assumed to result from activation of a-adrenergic receptors in the dorsal horn of the spinal cord.
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