Korean J Med.  2003 Nov;65(5):610-614.

A case of desmoplastic small round cell tumor

• Chung SH
• Lee SY
• Kum DS
• Kim SH
• Kwon HC
• Kim JS
• Kim HJ

Abstract

Desmoplastic small round cell tumor (DSRCT) is a rare neoplasm that develops in the abdominal cavity in young people. Microscopically, nests of small undifferentiated cells within a desmoplastic stroma are observed and immunohistochemical studies show polyphenotypic differentiation with expression of epithelial, neural and muscle markers. A specific chromosomal translocation, t (11;22)(p13;q12) has been documented in DSRCT and is increasingly used to confirm the diagnosis. We had experienced a 59-year-old female with right upper quardrant pain for 1 month. On abdominal computerized tomography, multiple demarcated intrahepatic mass lesions were found, but other organs metastasis or abnormal lymph node enlargement and fluid collection were not found. Fine needle aspiration biopsy of hepatic mass was performed and DSRCT was diagnosed by H and E and immunohistochemical staining. She was treated with cyclophosphamide, etoposide, doxorubicin and cisplatin. After three cycles of chemotherapy, computerized tomography demonstrated distinct shrinkage of tumor. At present, she continues in the state of partial remission for 15months after chemotherapy was started.

Keyword

Small round cell tumor; Desmoplastic; Polyphenotypic differentiation

MeSH Terms

Abdominal Cavity
Biopsy
Biopsy, Fine-Needle
Cisplatin
Cyclophosphamide
Desmoplastic Small Round Cell Tumor*
Diagnosis
Doxorubicin
Drug Therapy
Etoposide
Female
Humans
Lymph Nodes
Middle Aged
Neoplasm Metastasis
Translocation, Genetic
Cisplatin
Cyclophosphamide
Doxorubicin
Etoposide