Korean J Thorac Cardiovasc Surg.  2005 Nov;38(11):799-802.

Surgical Treatment of Langerhans Cell Histiocytosis in the Rib: Two cases report

• Lee YH
• Kang DK
• Park JM
• Han IY
• Jun HJ
• Yoon YC
• Hwang YH
• Cho KH

Abstract

Langerhans cell histiocytosis (LCH) involves disorders previously referred as "histiocytosis X" (including eosinophilic granuloma, Letterer-Siwe, and Hand-Schuller syndrome). Its clinical patterns are various and it is a basically benign tumoral condition but with a strong tendency toward dissemination and destruction. Its natural history is unpredictable. But, in solitary bone lesion, wide resection with tumor-free margin is required in order to provide the best chance for a cure. In the majority of patients LCH is a osteolytic lesion with a predilection for calvarium and is rarely seen in the skull base and the femur. LCH of rib, especially if solitary, is relatively rare. We report two rare cases of solitary LCH developed in the rib, which were successfully treated by surgical resection.

Keyword

Histiocytosis; Ribs; Rib neoplasm

MeSH Terms

Eosinophilic Granuloma
Femur
Histiocytosis
Histiocytosis, Langerhans-Cell*
Humans
Natural History
Ribs*
Skull
Skull Base