Korean J Blood Transfus.  2002 Dec;13(2):173-179.

A Case of Neonatal Alloimmune Thrombocytopenia due to Anti-HLA-B62+B75

• Lee JS
• Park BS
• Park HJ
• Sun YH
• Song EY
• Park MH
• Han KS

Abstract

We encountered a case of neonatal alloimmune thrombocytopenia (NAIT) due to anti-HLA-B62+B75. We incidentally find thrombocytopenia (14,000/uL at birth and decreased to 4,000/uL at 12 hours after birth) in a female fullterm neonate. Petechial skin lesions are developed on her back and buttock at second day of birth. Her mother suffered from preeclamsia during her last trimester, but her platelet count was 167,000/uL and she had no history of abnormal bleeding. Anti-HLA-B62+B75 antibody was identified in mother's serum by panel reactive antibody test and was reactive with father's platelet by mixed passive hemagglutination assay. Platelet concentrate was transfused at the second and 5th days and patient's platelet count rose up to 58,000/uL just after transfusion but decreased to 21,000/uL eventually. From the 8th day, gamma globulin (1g/kg/day) was started intravenously for 3 days and platelet count rose up to 128,000/uL at 13th day and remained within normal limit thereafter.

Keyword

Neonatal alloimmune thrombocytopenia (NAIT); Anti-HLA-B62+B75 antibody; Anti-HLA antibody

MeSH Terms

Blood Platelets
Buttocks
Female
gamma-Globulins
Hemagglutination
Hemorrhage
Humans
Infant, Newborn
Mothers
Parturition
Platelet Count
Pregnancy
Pregnancy Trimester, Third
Skin
Thrombocytopenia
Thrombocytopenia, Neonatal Alloimmune*
gamma-Globulins