Korean J Obstet Gynecol.  2011 Oct;54(10):582-590. 10.5468/KJOG.2011.54.10.582.

The effect of antenatal corticosteroid on incidence of respiratory distress syndrome according to maternal body mass index

• Jo EJ
• Kwak HM
• Ji HY
• Cha HH
• Choi SJ
• Oh SY
• Roh CR
• Kim JH

• KMID: 1836743
• DOI: http://doi.org/10.5468/KJOG.2011.54.10.582

Abstract

OBJECTIVE
To investigate the effects of antenatal corticosteroid (ACS) on incidence of neonatal respiratory distress syndrome (RDS) according to maternal body mass index (BMI).
METHODS
We retrospectively reviewed the medical records of 715 singleton pregnant women who delivered between 24+0 and 34+0 weeks of gestation, from January 1996 to December 2006. Subjects were categorized into three groups according to ACS exposure: a nonuser group (n = 244), a single-course group (n = 377) and a multiple-course group (n = 94). Subjects were re-categorized into three groups according to maternal BMI at admission: group 1 (BMI < 23.0 kg/m2, n = 234), group 2 (BMI 23.0-24.9 kg/m2, n = 166) and group 3 (BMI > or = 25.0 kg/m2, n = 315). Univariate and multiple logistic regression analyses were used for the statistical analysis.
RESULTS
Overall, the incidence of RDS was significantly lower in ACS-user groups than the non-user group, with lowest incidence in the multiple-course group (non-user vs. single-course vs. multiple-course: 44.3% vs. 41.1% vs. 11.7%, P < 0.001). The incidence of RDS was not different among the three BMI groups. Multiple logistic regression analysis showed that single- and multiple-course of ACS was significantly associated with reduced incidence of RDS: single-course, odds ratio (OR) 0.593, 95% confidence interval (CI) 0.373, 0.942; multiple-course, OR 0.085, 95% CI 0.034, 0.213. However, maternal BMI was not associated with reduced incidence of RDS with different ACS-courses (P for interaction = 0.690).
CONCLUSION
ACS therapy, especially when multiple-course was used, was significantly associated with reduced incidence of RDS, but maternal BMI did not influence its effectiveness.

Keyword

Preterm delivery; Antenatal corticosteroid; Respiratory distress syndrome; Maternal body mass index

MeSH Terms

Body Mass Index
Female
Humans
Incidence
Logistic Models
Medical Records
Morinda
Odds Ratio
Pregnancy
Pregnant Women
Respiratory Distress Syndrome, Newborn
Retrospective Studies

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