J Korean Soc Biol Psychiatry.  1998 Jun;5(1):122-128.

A Clinical Trial of Combined Treatment with Estrogen and Antipsychotics in Females with Chronic Schizophrenia

• Kwon EJ
• Kim JS
• Jung IK
• Lee DW

Abstract

OBJECTIVE
This study was a open clinical trial aimed at exploring the effectiveness of combined treatment with estrogen and antipsychotics to the chronic female schizophrenics. METHOD: 40 female patients who met DSM-VI criteria for schizophrenia who were chronically ill were randomly assigned to estrogen group(EG) and control group(CG). EG patients were received estrogen 1.25mg for 8 weeks in addition to their routine antipsychotic regimens. CG patients were received their routine antipsychotic regimens only. Both groups were evaluated by PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) at 0, 4, 8 week during the trial period and compaired with each other.
RESULTS
40 female patients have completed the study during 8 weeks. EG was significantly improved in PANSS and CGI scores than CG during the 8 weeks. In EG patients, all symptom subtypes(positive symptoms, negative symptoms, general psychopathology symptoms) of PANSS were significantly improved and positive symptoms were most significantly improved at 8 weeks.
CONCLUSIONS
This results support the clinical value of combined estrogen therapy among chronic female schizophrenics.

MeSH Terms

Antipsychotic Agents*
Chronic Disease
Estrogens*
Female*
Humans
Psychopathology
Schizophrenia*
Antipsychotic Agents
Estrogens