Korean Circ J.  2007 Jun;37(6):244-250. 10.4070/kcj.2007.37.6.244.

Impact of Optimal Stent Expansion on Late Outcomes after Sirolimus-Eluting Stent Implantation: An Intravascular Ultrasound Study

• Nam CW
• Kim KB
• Hur SH
• Cho YK
• Kim HS
• Han SW
• Kim YN
• Chung IS
• Lee YS
• Kim KS

• KMID: 1825857
• DOI: http://doi.org/10.4070/kcj.2007.37.6.244

Abstract

BACKGROUND AND OBJECTIVES: Sirolimus-eluting stents (SESs) have a considerably lower optimal minimal stent area (MSA) threshold compared to bare metal stents (BMSs). In the SIRIUS IVUS sub study, the absolute optimal stent expansion (OSE) of SESs was described as > or =5.0 mm2. The purpose of this study was to evaluate the impact of the OSE on long-term outcomes following SES implantation using absolute IVUS criteria.
SUBJECTS AND METHODS
The study included 157 patients (BMS: 57; SES; 100), who underwent 6-month follow-up angiography and 18-month clinical follow-up after bare metal stent or drug-eluting stent (DES) implantation. According to the absolute measurement IVUS criteria, patients were divided into two groups: OSE and non-OSE. The IVUS criteria for OSE were MSA > or =6.5 mm2 for BMS implantation and MSA > or =5.0 mm2 for SES implantation.
RESULTS
Angiographic binary restenosis was higher in the non-OSE than the OSE group with BMS (33.3% vs. 11.4%; p<0.039), but the rates were similar between the two groups with SES (4.5% vs. 3.2%; p=1.00). With the BMS, the MACE rates were 5.7% and 30% in the OSE and non-OSE group, respectively (p=0.017). However, with the SES, the MACE rates were similar between the two groups (OSE group, 3.2% vs. non-OSE group, 4.5%, p=1.00). CONSLUSION: After SES implantation, there were no significant differences in the late outcomes in relation to the achievement of absolute OSE. A variety of restenosis related factors should be considered for better outcomes after DES implantation. Therefore, the concept of OSE in the era of DESs might need to be revisited.

Keyword

Intravascular ultrasonography; Stents; Outcomes

MeSH Terms

Angiography
Drug-Eluting Stents
Follow-Up Studies
Humans
Stents*
Ultrasonography*
Ultrasonography, Interventional

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