Infect Chemother.  2004 Dec;36(6):377-380.

A Case of Systemic Vasculitis Presented as Fever of Unknown Origin

• Jung ES
• Kim CH
• Hyun YY
• Ko GJ
• Hwang BY
• Cheong HJ
• Kim WJ
• Won NH

Abstract

Fever of unknown origin (FUO) means fever that does not resolve spontaneously in the period expected for self-limited infection and whose cause cannot be ascertained despite considerable diagnostic efforts. We experienced a case of FUO associated with systemic vasculitis, which was diagnosed with clinical manifestation, radiographic findings, the presence of anti-neutrophil cytoplasmic antibody (ANCA), and renal biopsy. A 54-year-old female was admitted to our hospital with remittent fever of 3 months. A paranasal sinus (PNS) view revealed maxillary and ethmoidal sinusitis, and urine analysis showed microscopic hematuria. We performed a renal biopsy on the basis of positive ANCA and microscopic hematuria. The renal biopsy showed pauci-immune crescentic glomerulonephritis without granuloma, interstitial inflammation, and small vessel vasculitis. Under the diagnosis of ANCA-associated systemic vasculitis, she was treated with steroid and cyclophosphamide. She showed marked clinical improvement.

Keyword

Fever of unknown origin (FUO); Systemic vasculitis; ANCA

MeSH Terms

Antibodies, Antineutrophil Cytoplasmic
Biopsy
Cyclophosphamide
Diagnosis
Ethmoid Sinusitis
Female
Fever of Unknown Origin*
Fever*
Glomerulonephritis
Granuloma
Hematuria
Humans
Inflammation
Malaria
Middle Aged
Systemic Vasculitis*
Vasculitis
Antibodies, Antineutrophil Cytoplasmic
Cyclophosphamide