Intest Res.  2012 Jul;10(3):289-294. 10.5217/ir.2012.10.3.289.

Recurrent Acute Pericarditis Induced by 5-aminosalicylates in a Patient with Inflammatory Bowel Disease

• Choi AR
• Kim MN
• Lee JH
• Lee YK
• Park YH
• Shin HS
• Oh TG
• Park HJ
• Park MS
• Lim S
• Park SJ
• Hong SP
• Kim TI
• Kim WH
• Cheon JH

• KMID: 1807262
• DOI: http://doi.org/10.5217/ir.2012.10.3.289

Abstract

Inflammatory bowel disease (IBD) is an idiopathic chronic inflammation of the intestines. IBD treatment may require anti-inflammatory agents such as sulfasalazine or 5-aminosalicylate (5-ASA) and immunomodulators to control the symptoms. However, these agents have a variety of common adverse effects such as nausea, vomiting, skin rash, leukopenia, thrombocytopenia, and infections. Moreover, rare side effects such as nephrotic syndrome, pneumonitis, and pericarditis can occur. A 21-year-old male was admitted to the hospital due to acute chest pain, fever, and sweating. The patient had a history of Crohn's disease and had been taking mesalazine for 3 weeks. Chest x-ray, echocardiography, and clinical manifestations revealed that the patient had acute pericarditis. However, we did not recognize the relationship between these findings and 5-ASA at that time. Two years later, the patient took 5-ASA again, and similar symptoms occurred, which led us to confirm that he suffered from pericarditis induced by this drug. We report a case of acute recurrent pericarditis that developed after taking 5-ASA for IBD treatment with a review of the literature.

Keyword

Crohn Disease; Colitis, Ulcerative; Mesalamine; Pericarditis

MeSH Terms

Anti-Inflammatory Agents
Chest Pain
Colitis, Ulcerative
Crohn Disease
Echocardiography
Exanthema
Fever
Humans
Immunologic Factors
Inflammation
Inflammatory Bowel Diseases
Intestines
Leukopenia
Male
Mesalamine
Nausea
Nephrotic Syndrome
Pericarditis
Pneumonia
Sulfasalazine
Sweat
Sweating
Thorax
Thrombocytopenia
Vomiting
Young Adult
Anti-Inflammatory Agents
Immunologic Factors
Mesalamine
Sulfasalazine