Korean J Dermatol.  2014 Apr;52(4):269-273.

A Case of Large Cell Lung Carcinoma with Rhabdoid Phenotype Presenting as Cutaneous Metastasis

• Seo HM
• Kim JI
• Kim YH
• Min JH
• Lee SJ
• Park JH
• Kim WS
• Lee GY

Abstract

Large cell carcinoma with a rhabdoid phenotype is very rare. We report the case of a 53-year-old man who presented with multiple nodules on the scalp, face, and trunk. A skin biopsy revealed large cell carcinoma with a rhabdoid phenotype throughout the dermis. Tumor cells had abundant cytoplasm, eccentric nuclei, and prominent nucleoli and did not adhere to each other. Immunohistochemical tests showed positive reactions for vimentin, epithelial membrane antigen (EMA), and thyroid transcription factor-1 (TTF-1) and weakly focal reactions for pan-CK, CK7, and p63. Imaging studies and a percutaneous lung biopsy were performed and the results were consistent with a large cell lung carcinoma with a rhabdoid phenotype. Based on these clinical and histopathological findings, we concluded that his condition was a cutaneous metastasis from a large cell lung carcinoma with a rhabdoid phenotype, which occurs very rarely.

Keyword

Cutaneous metastasis; Large cell lung carcinoma with rhabdoid phenotype; Rhabdoid tumor

MeSH Terms

Biopsy
Carcinoma, Large Cell
Cytoplasm
Dermis
Humans
Lung*
Middle Aged
Mucin-1
Neoplasm Metastasis*
Phenotype*
Rhabdoid Tumor
Scalp
Skin
Thyroid Gland
Vimentin
Mucin-1
Vimentin