J Korean Med Sci.  2011 Feb;26(2):174-183. 10.3346/jkms.2011.26.2.174.

Etiology of Invasive Bacterial Infections in Immunocompetent Children in Korea (1996-2005): A Retrospective Multicenter Study

Affiliations
  • 1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. hoanlee@snu.ac.kr
  • 2Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea.
  • 3Department of Pediatrics, College of Medicine, Soonchunhyang University, Seoul, Korea.
  • 4Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital, Seoul, Korea.
  • 5Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea.
  • 6Department of Pediatrics, College of Medicine, Kyunghee University, Seoul, Korea.
  • 7Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea.
  • 8Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 9Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
  • 10Department of Pediatrics, Inha University College of Medicine, Incheon, Korea.
  • 11Department of Pediatrics, Dankook University College of Medicine, Cheonan, Korea.
  • 12Department of Pediatrics, College of Medicine, Pusan National University, Busan, Korea.
  • 13Department of Pediatrics, Chonnam National University Medical School, Gwangju, Korea.
  • 14Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea.
  • 15Department of Pediatrics, Yonsei University Wonju College of Medicine, Wonju, Korea.

Abstract

The purpose of this study was to identify the major etiological agents responsible for invasive bacterial infections in immunocompetent Korean children. We retrospectively surveyed invasive bacterial infections in immunocompetent children caused by eight major pediatric bacteria, namely Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pyogenes, Listeria monocytogenes, and Salmonella species that were diagnosed at 18 university hospitals from 1996 to 2005. A total of 768 cases were identified. S. agalactiae (48.1%) and S. aureus (37.2%) were the most common pathogens in infants younger than 3 months. S. agalactiae was a common cause of meningitis (73.0%), bacteremia without localization (34.0%), and arthritis (50%) in this age group. S. pneumoniae (45.3%) and H. influenzae (20.4%) were common in children aged 3 months to 5 yr. S. pneumoniae was a common cause of meningitis (41.6%), bacteremia without localization (40.0%), and bacteremic pneumonia (74.1%) in this age group. S. aureus (50.6%), Salmonella species (16.9%), and S. pneumoniae (16.3%) were common in older children. A significant decline in H. influenzae infections over the last 10 yr was noted. S. agalactiae, S. pneumoniae, and S. aureus are important pathogens responsible for invasive bacterial infections in Korean children.

Keyword

Bacterial Infections; Epidemiology; Bacteremia; Meningitis; Streptococcus agalactiae; Streptococcus pneumonia; Staphylococcus aureus
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