Korean J Lab Med.  2007 Jun;27(3):188-191. 10.3343/kjlm.2007.27.3.188.

Acute Hemolysis and Renal Failure caused by Hepatitis A Infection with Underlying Glucose-6-Phosphate Dehydrogenase Deficiency

• Jekarl DW
• Oh EJ
• Park YJ
• Han KJ
• Lee SW
• Park CW

• KMID: 1781482
• DOI: http://doi.org/10.3343/kjlm.2007.27.3.188

Abstract

Although glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme disorder worldwide, it has rarely been reported among Korean. The patient was previously healthy 39 yr old male who showed severe hemolytic anemia and acute renal failure accompanied by hyperbilirubinemia after hepatitis A infection. The additional studies for differential diagnosis of hemolytic anemia showed a moderate deficiency of G6PD enzyme. Because hepatitis A infection in patient with G6PD deficiency present much more severe clinical symptoms, G6PD enzyme should be examined in patients with triggering factors of hemolysis such as hepatitis A infection.

Keyword

Glucose-6-phosphate dehydrogenase deficiency; Hepatitis A virus; Hemolytic anemia; Acute renal failure

MeSH Terms

Adult
Diagnosis, Differential
Glucosephosphate Dehydrogenase/genetics
Glucosephosphate Dehydrogenase Deficiency/*complications/diagnosis
*Hemolysis
Hepatitis A/*complications/diagnosis
Hepatitis A Virus, Human/isolation & purification
Humans
Hyperbilirubinemia/etiology
Kidney Failure, Acute/*diagnosis/etiology
Male

Figure

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  Fig. 1. Leukoerythroblastic reaction and thrombocytosis in peripheral blood smear (A) (Wright Giemsa stain, ×400). Normal cellularity with erythroid hyperplasia in bone marrow aspirate smear (B) (×1,000).

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