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Assay Sensitivity Difference Can Induce Anti-Hepatitis A Virus IgM Non-Reactive But Total (IgM and IgG) Reactive Results in Early Acute Hepatitis A

Kim SK, Yoo K, Huh J

Although anti-hepatitis A virus (HAV) IgM non-reactive and anti-HAV total (immunoglobulin [Ig] M and IgG) reactive results are generally interpreted as immunity to HAV, some early acute hepatitis A patients...
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Diagnostic Accuracy of Machine Learning Algorithms for Hepatitis A Antibody

Lim J

Purpose: The objective of this study was to develop a model for predicting the positivity of hepatitis A antibody based on nationwide health information using a machine learning technique. Methods: We...
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Epidemiological and Clinical History of Viral Hepatitis in Korea

Yoon JH, Cho SH, Kim DY, Yu SJ, Han KH

Viral hepatitis is the most important cause of acute and chronic liver disease in Korea. Particularly, hepatitis B virus (HBV) is the leading cause of liver-related mortality. Because of the nationwide...
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A Study on Seroprevalence of Hepatitis A Virus among Healthcare Workers at a University-Affiliated Hospital in Deajeon, Korea

Ji SK, Jang SH, Park MH, Lee JE, Jeong HS, Park J, Han SB, Yi Y, Park SH

Background: In 2019, there was an outbreak of hepatitis A virus (HAV) infections in Korea. This study was performed to determine the seroprevalence of HAV among healthcare workers (HCWs) in...
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Seroprevalence of Hepatitis A Virus in Pediatric Patients with Hematologic Malignancies after Chemotherapy and Hematopoietic Cell Transplantation

Moon JU, Han AL, Lee ES, Kim SK, Han SB, Lee JW, Chung NG, Cho B, Jeong DC, Kang JH

This retrospective study was performed to determine the seroprevalence of hepatitis A virus (HAV) in children and adolescents with hematologic malignancies after the completion of chemotherapy and hematopoietic cell transplantation...
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Causes and countermeasures for repeated outbreaks of hepatitis A among adults in Korea

Ki M, Son H, Choi BY

The 2019 hepatitis A outbreak has become increasingly prevalent among adults in Korea and is the largest outbreak since that in 2009–2010. The incidence in the current outbreak is highest...
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A Case of Graves' Disease Accompanied with Acute Hepatitis A Virus Infection

Hong SE, Choo JW, Lim SK, Lee SJ, Park JW, Kim SE, Kim JH, Park CK

Concurrent presentation of acute hepatitis A virus (HAV) infection and Graves' disease has not been reported in literature worldwide. Although there is no well-established mechanism that explains the induction of...
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Acute-onset chronic inflammatory demyelinating polyneuropathy following hepatitis A virus infection

Jung ES, Kim YS, Min JH, Kang K, Lee JJ, Park JM, Kim BK, Kwon O

An infection is less likely to elicit chronic inflammatory demyelinating polyneuropathy (CIDP) than Guillain-Barré syndrome. We here report a case of acute-onset CIDP following hepatitis A virus infection and briefly...
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Antibodies against Hepatitis A and Hepatitis B Virus in Intravenous Immunoglobulin Products

Lee S, Kim HW, Kim KH

The worldwide seroprevalence of hepatitis A virus (HAV) and hepatitis B virus (HBV) has changed over the last two decades, indicating a declining incidence of HAV and HBV infections. Therefore,...
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Comparative Analysis of Liver Injury-Associated Cytokines in Acute Hepatitis A and B

Shin SY, Jeong SH, Sung PS, Lee J, Kim HJ, Lee HW, Shin EC

PURPOSE: Acute hepatitis A (AHA) and acute hepatitis B (AHB) are caused by an acute infection of the hepatitis A virus and the hepatitis B virus, respectively. In both AHA...
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Comparative Genotype Analysis of Hepatitis A Virus: Two One-Year Studies in South Korea in 2002 and 2011

Baek IH, Lee HW, Kim HJ, Song MO, Yoon SK, Park JH, Chung IS, Kim W

Hepatitis A virus (HAV) positive stool samples were collected from acute hepatitis A patients during the two study periods of 2002 and 2011 in Seoul, South Korea, and their genetic...
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Changes in the seroprevalence of IgG anti-hepatitis A virus between 2001 and 2013: experience at a single center in Korea

Chung SJ, Kim TY, Kim SM, Roh M, Yu MY, Lee JH, Oh C, Lee EY, Lee S, Jeon YC, Yoo KS, Sohn JH

BACKGROUND/AIMS: The incidence of symptomatic hepatitis A reportedly increased among 20- to 40-year-old Korean during the late 2000s. Vaccination against hepatitis A was commenced in the late 1990s and was...
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The Immunogenicity of a Single Dose of Hepatitis A Virus Vaccines (Havrix(R) and Epaxal(R)) in Korean Young Adults

Lim J, Song YJ, Park WS, Sohn H, Lee MS, Shin DH, Kim CB, Kim H, Oh GJ, Ki M

PURPOSE: Assessing the immunogenicity of a single dose of hepatitis A virus (HAV) vaccines is important because some people receive only a single dose. However, previous studies have shown variable...
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Comparison of 3 Automated Immunoassays for Detection of Anti-Hepatitis A Virus Immunoglobulin M in a Tertiary Care Hospital

Park H, Lee YJ, Seong MW, Lee DH, Park MH, Song EY

Three automated immunoassay kits for anti-Hepatitis A Virus (HAV) IgM-Architect, (Abbott Laboratories, USA), Elecsys (Roche Diagnostics, Germany), and ADVIA Centaur (Siemens Healthcare Diagnostics Inc., USA)-were compared. We included 178 consecutive...
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Influenza A (H1N1) 2009 Pandemic Calm Down the Prevalence of Acute Hepatitis A in the Latter Half of 2009: Korean Population Study

Byun JM, Kim SG, Zhang YY, Kim YS, Jeong SW, Lee SH, Jang JY, Hong SJ, Moon JH, Kim HS, Lee MS, Kim BS

BACKGROUND/AIMS: There was a spiking incidence of acute hepatitis A (AHA) in 2009 summer, but it went down drastically after an outbreak of influenza A (H1N1). We assessed the relationship...
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Seroepidemiology of Hepatitis A Infection in Northeastern China, Korea, and Japan

Yun H, Lee HJ, Yoon Y, Kim K, Kim S, Shin MH, Taniguchi M, Kim SR, Kim MK

Objectives The epidemiological patterns of endemic hepatitis A virus (HAV) are unclear in northeastern Asia depending on the ethnicity of the country in question. The purpose of this study was to...
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Enhancement of Protein Productivity of Recombinant Hepatitis A Virus VP1 in Stably Transfected Drosophila melanogaster S2 Cells

Jeon HB, Park JH, Lee HH, Kim DH, Lee HY, Shon DH, Kim W, Chung IS

The effect of DMSO and sodium butyrate on the production of recombinant hepatitis A virus (HAV) capsid protein VP1 was evaluated and optimized in the culture of stably transfected Drosophila...
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Prevention of Viral Hepatitis and Vaccination

Cho YK, Song BC

  • KMID: 2263635
  • Korean J Med.
  • 2012 Feb;82(2):123-133.
Hepatitis viruses are most important cause of acute and chronic hepatitis. In past, hepatitis B virus was one of the major causes of acute hepatitis. Recently, around 60-70% of acute...
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Comparison of Two Automated Immunoassays for the Detection of Anti-Hepatitis A Virus Total Immunoglobulin and IgM

Shin SY, Lim HJ, Yi C, Yu S, Kwon MJ, Park H, Kim YJ, Jung CL, Woo HY

  • KMID: 2145395
  • J Lab Med Qual Assur.
  • 2011 Dec;33(2):103-109.
BACKGROUND: The detection of total anti-hepatitis A virus (anti-HAV) immunoglobulin (Ig) and IgM is important for diagnosing acute hepatitis A. Our laboratory introduced new commercial automated chemiluminescence immunoassays (CLIAs) for...
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Coinfection of hepatitis A virus genotype IA and IIIA complicated with autoimmune hemolytic anemia, prolonged cholestasis, and false-positive immunoglobulin M anti-hepatitis E virus: a case report

Kim HS, Jeong SH, Jang JH, Myung HJ, Kim JW, Bang SM, Song SH, Kim H, Yun HS

A 37-year-old male presented with fever and jaundice was diagnosed as hepatitis A complicated with progressive cholestasis and severe autoimmune hemolytic anemia. He was treated with high-dose prednisolone (1.5 mg/kg),...
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