Ann Lab Med.  2014 Jan;34(1):60-63. 10.3343/alm.2014.34.1.60.

Four Cases of Chronic Myelogenous Leukemia in Mixed Phenotype Blast Phase at Initial Presentation Mimicking Mixed Phenotype Acute Leukemia with t(9;22)

• Choi W
• Kim M
• Lim J
• Han K
• Lee S
• Lee JW
• Chung NG
• Kim Y

• KMID: 1781362
• DOI: http://doi.org/10.3343/alm.2014.34.1.60

Abstract

No abstract available.

MeSH Terms

Acute Disease
Child
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 9
Female
Fusion Proteins, bcr-abl/genetics
Humans
In Situ Hybridization, Fluorescence
Leukemia/*genetics/pathology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics/pathology
Male
Middle Aged
Phenotype
*Translocation, Genetic
Fusion Proteins, bcr-abl

Figure

• 

  Fig. 1 Interphase FISH results of case 2. (A) FISH analysis using a BCR/ABL1 Dual color, Dual fusion Translocation Probe, which showed a green signal (native BCR), a red signal (native ABL1), a fused signal, and a smaller green signal, indicating BCR-ABL1 and a loss of ABL1 in neutrophils as well as blasts: nuc ish(ABL1X2),(BCRX3),(ABL1 con BCRX1)[390/400]. (B) FISH analysis using BCR/ABL1 extra signal (ES) Dual Color Translocation Probe, which revealed a green signal (native BCR), a red signal (native ABL1), and a fused signal without a smaller red signal (ES) in neutrophils as well as blasts. The absence of the smaller red signal indicates the loss of ABL1. While using BCR/ABL1 ES probe, if there is no loss of ABL1, a fusion signal and a smaller red extra signal indicate major BCR-ABL1, and 2 fusion signals indicate minor BCR-ABL1. The results of case 2 indicate major BCR-ABL1: nuc ish(ABL1X2),(BCRX2),(ABL1 con BCRX1)[390/400].

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