Korean J Urol.  2009 Aug;50(8):744-750. 10.4111/kju.2009.50.8.744.

CyberKnife(TM) for the Treatment of Non-Metastatic Prostate Cancer

  • 1Department of Urology, Korea Cancer Center Hospital, Seoul, Korea. andrea@kcch.re.kr


The radiobiology of prostate cancer favors a hypofractionated dose regimen. We report here our experience with the CyberKnife(TM), demonstrating its efficacy, safety, and feasibility as a treatment modality for non-metastatic prostate cancer. MATERIALS AND METHODS: Between October 2002 and April 2006, 20 patients with biopsy-proven prostate cancer were treated with the CyberKnife(TM). The distribution of clinical risks, as assessed by using D'Amico's definition for risk grouping, was as follows: low (4), intermediate (5), and high (11). Three patients received 32 Gy, 7 patients received 34 Gy, and 10 patients received 36 Gy. All patients received the radiation doses in 4 fractions. The rectal and bladder toxicities were graded by using the criteria set forth by the Radiation Therapy Oncology Group (RTOG). RESULTS: The mean patient age was 71.4 years (range, 52-79 years), and the mean follow-up period was 35.5 months (range, 8-74 months). There were 2 acute and 1 late grade 2 gastrointestinal toxicities, and 1 acute and 2 late grade 2 urinary toxicities. The 5-year overall survival rate was 100%, respectively. The 5-year biochemical failure-free rate of the low-risk, intermediate-risk, and high-risk patients was 100%, 100%, and 90.9%, respectively. CONCLUSIONS: CyberKnife(TM) is a safe, well-tolerated, and rather effective treatment for non-metastatic prostate cancer. We obtained a 100% 5-year biochemical failure-free rate in low-risk and intermediate-risk patients. CyberKnife(TM) is a viable option for the treatment of non-metastatic prostate cancer.


Prostatic neoplasms; Radiation; Radiosurgery

MeSH Terms

Follow-Up Studies
Prostatic Neoplasms
Survival Rate
Urinary Bladder


  • Fig. 1. CyberKnifeTM treatment planning for prostate and critical organs in the Accuray multiplan system.

  • Fig. 2. Prostate-specific antigen (PSA) response plotted as mean PSA as a function of time after CyberKnifeTM treatment. The error bar indicates ±1 SD from the mean. SD: standard deviation, CK: CyberKnifeTM.

  • Fig. 3. Kaplan-Meier actuarial probability of the biochemical failure-free survival rate according to risk group. CK: CyberKnifeTM.


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