J Korean Med Sci.  2013 Jul;28(7):1089-1094. 10.3346/jkms.2013.28.7.1089.

Morbidity and Mortality in Jeju Residents over 50-Years of Age with Hip Fracture with Mean 6-Year Follow-Up: A Prospective Cohort Study

Affiliations
  • 1Department of Orthopedic Surgery, Halla General Hospital, Jeju, Korea.
  • 2Department of Orthopedic Surgery, Chung-Ang University College of Medicine, Seoul, Korea. hayongch@naver.com
  • 3Department of Anesthesiology, Chung-Ang University College of Medicine, Seoul, Korea.
  • 4Department of Orthopedic Surgery, Jeju National University School of Medicine, Jeju, Korea.

Abstract

This prospective cohort study was performed to estimate the morbidity and mortality with 790 patients over 50-yr of age that sustained a femoral neck or intertrochanteric fracture from 2002 to 2006, followed-up for a mean of 6 yr (range, 4 to 9 yr). Crude and annual standardized mortality ratios (SMRs) were calculated; and mortalities in the cohort and the age and sex matched general population were compared. The risk factors on mortality and activities pre- and post-injury were assessed. Accumulated mortality was 16.7% (132 patients) at 1 yr, 45.8% (337 patients) at 5 yr, and 60% (372 patients) at 8 yr. SMR at 5 yr post-injury was 1.3 times that of the general population. Multivariate analysis demonstrated that age (OR, 1.074; 95% CI, 1.050-1.097; P<0.001), woman (OR, 1.893; 95% CI, 1.207-2.968; P=0.005), and medical comorbidity (OR, 1.334; 95% CI, 1.167-1.524 P<0.001) were independently associated with mortality after hip fracture. Only 59 of the 150 patients (39.3%) who were able to ambulate normally outdoors at preinjury retained this ability at final follow-up. Patients with a hip fracture exhibits higher mortality at up to 5 yr than general population. Age and a preinjury comorbidity are associated with mortality.

Keyword

Hip Fracture; Mortality; Standardized Mortality Ratio; Risk Factor; Morbidity

MeSH Terms

Age Factors
Aged
Aged, 80 and over
Aging
Cohort Studies
Female
Hip Fractures/*epidemiology/mortality
Humans
Male
Prospective Studies
Republic of Korea/epidemiology
Risk Factors
Sex Factors

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Reference

1. Kanis JA, Oden A, Johnell O, De Laet C, Jonsson B, Oglesby AK. The components of excess mortality after hip fracture. Bone. 2003; 32:468–473.
2. Kim SR, Ha YC, Park YG, Lee SR, Koo KH. Orthopedic surgeon's awareness can improve osteoporosis treatment following hip fracture: a prospective cohort study. J Korean Med Sci. 2011; 26:1501–1507.
3. Abrahamsen B, van Staa T, Ariely R, Olson M, Cooper C. Excess mortality following hip fracture: a systematic epidemiological review. Osteoporos Int. 2009; 20:1633–1650.
4. Yoon HK, Park C, Jang S, Jang S, Lee YK, Ha YC. Incidence and mortality following hip fracture in Korea. J Korean Med Sci. 2011; 26:1087–1092.
5. Richmond J, Aharonoff GB, Zuckerman JD, Koval KJ. Mortality risk after hip fracture. J Orthop Trauma. 2003; 17:53–56.
6. Bliuc D, Nguyen ND, Milch VE, Nguyen TV, Eisman JA, Center JR. Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA. 2009; 301:513–521.
7. Paksima N, Koval KJ, Aharanoff G, Walsh M, Kubiak EN, Zuckerman JD, Egol KA. Predictors of mortality after hip fracture: a 10-year prospective study. Bull NYU Hosp Jt Dis. 2008; 66:111–117.
8. Tsuboi M, Hasegawa Y, Suzuki S, Wingstrand H, Thorngren KG. Mortality and mobility after hip fracture in Japan: a ten-year follow-up. J Bone Joint Surg Br. 2007; 89:461–466.
9. Borgquist L, Ceder L, Thorngren KG. Function and social status 10 years after hip fracture: prospective follow-up of 103 patients. Acta Orthop Scand. 1990; 61:404–410.
10. Cooper C, Atkinson EJ, Jacobsen SJ, O'Fallon WM, Melton LJ 3rd. Population-based study of survival after osteoporotic fractures. Am J Epidemiol. 1993; 137:1001–1005.
11. Kim SR, Ha YC, Kim JR, Kim R, Kim SY, Koo KH. Incidence of hip fractures in Jeju Island, South Korea: a prospective study (2002-2006). Clin Orthop Surg. 2010; 2:64–68.
12. Korea National Statistical Office. accessed 5 January 2010. Available at http://www.kosis.kr.
13. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987; 40:373–383.
14. Mullen JO, Mullen NL. Hip fracture mortality: a prospective, multifactorial study to predict and minimize death risk. Clin Orthop Relat Res. 1992; 280:214–222.
15. Tosteson AN, Gottlieb DJ, Radley DC, Fisher ES, Melton LJ 3rd. Excess mortality following hip fracture: the role of underlying health status. Osteoporos Int. 2007; 18:1463–1472.
16. Vestergaard P, Rejnmark L, Mosekilde L. Increased mortality in patients with a hip fracture-effect of pre-morbid conditions and post-fracture complications. Osteoporos Int. 2007; 18:1583–1593.
17. Fransen M, Woodward M, Norton R, Robinson E, Butler M, Campbell AJ. Excess mortality or institutionalization after hip fracture: men are at greater risk than women. J Am Geriatr Soc. 2002; 50:685–690.
18. Forsén L, Sogaard AJ, Meyer HE, Edna T, Kopjar B. Survival after hip fracture: short- and long-term excess mortality according to age and gender. Osteoporos Int. 1999; 10:73–78.
19. Farahmand BY, Michaëlsson K, Ahlbom A, Ljunghall S, Baron JA. Swedish Hip Fracture Study Group. Survival after hip fracture. Osteoporos Int. 2005; 16:1583–1590.
20. Meyer HE, Tverdal A, Falch JA, Pedersen JI. Factors associated with mortality after hip fracture. Osteoporos Int. 2000; 11:228–232.
21. Lee KH, Ha YC, Lee YK, Kang H, Koo KH. Frequency, risk factors, and prognosis of prolonged delirium in elderly patients after hip fracture surgery. Clin Orthop Relat Res. 2011; 469:2612–2620.
22. Bhattacharyya T, Iorio R, Healy WL. Rate of and risk factors for acute inpatient mortality after orthopaedic surgery. J Bone Joint Surg Am. 2002; 84:562–572.
23. Hannan EL, Magaziner J, Wang JJ, Eastwood EA, Silberzweig SB, Gilbert M, Morrison RS, McLaughlin MA, Orosz GM, Siu AL. Mortality and locomotion 6 months after hospitalization for hip fracture: risk factors and risk-adjusted hospital outcomes. JAMA. 2001; 285:2736–2742.
24. Poór G, Atkinson EJ, O'Fallon WM, Melton LJ 3rd. Determinants of reduced survival following hip fractures in men. Clin Orthop Relat Res. 1995; 319:260–265.
25. Hasegawa Y, Suzuki S, Wingstrand H. Risk of mortality following hip fracture in Japan. J Orthop Sci. 2007; 12:113–117.
26. Ceder L, Thorngren KG, Wallden B. Prognostic indicators and early home rehabilitation in elderly patients with hip fractures. Clin Orthop Relat Res. 1980; 152:173–184.
27. Koval KJ, Skovron ML, Aharonoff GB, Zuckerman JD. Predictors of functional recovery after hip fracture in the elderly. Clin Orthop Relat Res. 1998; 348:22–28.
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