Korean J Dermatol.
2008 Aug;46(8):1129-1133.
A Case of Palisaded Neutrophilic and Granulomatous Dermatitis
- Affiliations
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- 1Department of Dermatology, School of Medicine, Gyeongsang National University, Jinju, Korea.
- 2Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, Korea.
- 3Department of Dermatology and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju, Korea. jaymax1@dreamwiz.com
Abstract
- Palisaded neutrophilic and granulomatous dermatitis (PNGD) is an uncommon skin eruption associated with immune-mediated connective tissue diseases such as rheumatoid arthritis, lupus erythematosus, and Behcet's disease. This condition is also described as Winkelmann's granuloma, linear subcutaneous bands, rheumatoid papules, rheumatoid neutrophilic dermatitis, interstitial granulomatous dermatitis with cutaneous cords and arthritis, or Churg-Strauss disease. PNGD shows variable clinical manifestations and is characterized histopathologically by step pattern of early leukocytoclastic vasculititis, progressing to form palisaded granulomatous inflammation, and surrounding zones of necrobiosis in the later stages. We report a 66-year-old woman with multiple skin nodules, who had concomitant rheumatoid arthritis. Histopathologic findings revealed palisaded neutrophilic and granulomatous dermatitis.
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