J Breast Cancer.  2007 Jun;10(2):147-152. 10.4048/jbc.2007.10.2.147.

Toxicity of Concurrent Adjuvant CMF Chemotherapy and Radiotherapy in Patients with Early Breast Cancer

• Yom CK
• Kim HA
• Moon BI
• Choe KJ
• Choi KJ
• Suh HS
• Choi HY

• KMID: 1745056
• DOI: http://doi.org/10.4048/jbc.2007.10.2.147

Abstract

PURPOSE: Many patients with early stage breast cancer are currently being treated with both adjuvant chemotherapy (CT) and radiotherapy (RT). We performed this study to assess the toxicity of concurrent adjuvant cyclophosphamide, methotrexate, and 5-fluourouracil (CMF) CT and RT for treating early breast cancer patients.
METHODS
Between January 2000 and December 2005, 97 patients with stage I or II invasive breast carcinoma were treated with breast-conserving surgery, and they received 6 monthly cycles of classic oral chemotherapy with CMF. Within day 7 of cycle 1, the patients started 3 dimensional conformal RT (3DCRT) with a stadard dose, followed by a boost. We used the Common Terminology Criteria for Adverse Events v 3.0 to score the level of acute toxicity for CT. The adverse effects of RT were graded according to the Radiation Therapy Oncology Group criteria.
RESULTS
The mean age of the patients was 45.8 yr (range:30-64). The most common toxicity was nausea and leukopenia. The dose of chemotherapy was reduced to 80% of the planned dose for 6.2% of the patient. CT was disrupted for 4.1% of the patients. RT was not disrupted for any patient. Grade 3 and 4 neutropenia occurred in 41 (42.3%) patients, but only one patient needed hospitalization due to fever. Grade 3 skin lesions developed during or shortly after RT in 10.7% of the patients. Radiation penumonitis was noted in 15.5% of the patients. The median follow-up time was 38 months. There was no local recurrence and 2 (2.08%) distant metastases during follow-up.
CONCLUSION
From the results of our study, we conclude that the concurrent administration of adjuvant CMF CT and RT is associated with a low risk of serious toxicity and this is an acceptable adjuvant regimen for patients with early stage breast cancer.

Keyword

Concurrent; CMF chemotherapy; Radiotherapy; Toxicity

MeSH Terms

Breast Neoplasms*
Breast*
Chemotherapy, Adjuvant
Cyclophosphamide
Drug Therapy*
Fever
Follow-Up Studies
Hospitalization
Humans
Leukopenia
Mastectomy, Segmental
Methotrexate
Nausea
Neoplasm Metastasis
Neutropenia
Radiotherapy*
Recurrence
Skin
Cyclophosphamide
Methotrexate

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