J Korean Med Sci.  2000 Aug;15(4):393-398. 10.3346/jkms.2000.15.4.393.

Clinicopathologic study of Castleman's disease in Korea

• Kim JE
• Kim CJ
• Park IA
• Kim WH
• Seo JW
• Jang JJ
• Kim CW
• Park SH
• Lee HS
• Chi JG
• Kim YI
• Ham EK

• KMID: 1730634
• DOI: http://doi.org/10.3346/jkms.2000.15.4.393

Abstract

Castleman's disease represents an atypical lymphoproliferative disorder, infrequently associated with various immunologic abnormalities or subsequent development of malignancy such as Kaposi sarcoma, malignant lymphoma and plasmacytoma. Its clinicopathologic features depend on various etiologic factors such as Kaposi sarcoma herpesvirus (KSHV), oversecretion of IL-6, adhesion molecule and follicular dendritic cell dysplasia, etc. To investigate the relationship of Castleman's disease (CD) and the above factors, we reviewed 22 cases of CD. Four cases of KSHV positive CD were detected, all multicentric, plasma cell type, and these cases displayed prominent vascular proliferation, characteristic 'Kaposi-like lesion'. IL-6 and CD54 positive mononuclear cells were scattered in interfollicular areas of KSHV positive cases. Follicular dendritic cell hyperplasia, vascular proliferation, expression of IL-6 and CD54 did not show any significant difference between solitary vs multicentric type, and plasma cell type vs hyaline vascular type. Our study suggests that KSHV positive CD reveals unique pathologic features, and the probable relationship of KSHV and IL-6 and CD54 is discussed.

Keyword

Giant Lymph Node Hyperplasia; Herpesvirus, Kaposi Sarcoma-Associated; Sarcoma, Kaposi; Dendritic Cells, Follicular; Interleukin-6; Intercellular Adhesion Molecule-1

MeSH Terms

Adolescence
Adult
Biological Markers
Dendritic Cells, Follicular/pathology
Epstein-Barr Virus Infections/virology
Epstein-Barr Virus Infections/epidemiology
Female
Germinal Center/pathology
Giant Lymph Node Hyperplasia/virology
Giant Lymph Node Hyperplasia/pathology+ACo-
Giant Lymph Node Hyperplasia/epidemiology
Giant Lymph Node Hyperplasia/classification
Herpesviridae Infections/virology
Herpesviridae Infections/epidemiology
Herpesvirus 4, Human/isolation +ACY- purification
Herpesvirus, Kaposi Sarcoma-Associated/isolation +ACY- purification
Human
Hyperplasia
Intercellular Adhesion Molecule-1/analysis
Interleukin-6/analysis
Korea/epidemiology
Lymph Nodes/virology
Lymph Nodes/pathology
Lymph Nodes/chemistry
Male
Middle Age
Neovascularization, Pathologic
Receptors, Complement 3d/analysis
Retrospective Studies
Tumor Virus Infections/virology
Tumor Virus Infections/epidemiology