J Rheum Dis.  2013 Feb;20(1):59-63. 10.4078/jrd.2013.20.1.59.

A Case of Castleman's Disease Accompanied with Systemic Lupus Erythematosus

• Park SH
• Lee SG
• Kim SM
• Kim GT
• Baek SH
• Park YE

• KMID: 2223052
• DOI: http://doi.org/10.4078/jrd.2013.20.1.59

Abstract

Castleman's disease is a rare atypical lymphoproliferative disorder. Although HHV-8 has been reported to be a cause of Castleman's disease, the etiology and pathogenesis of the disease remains mostly unknown. We experienced a 51-year-old female patient who was concurrently diagnosed with Castleman's disease and systemic lupus erythematosus. Castleman's disease has been rarely reported in patients with systemic lupus erythematosus. Thus, we report the case and briefly discuss relevant articles.

Keyword

Castleman's disease; Systemic lupus erythematosus

MeSH Terms

Female
Giant Lymph Node Hyperplasia
Herpesvirus 8, Human
Humans
Lupus Erythematosus, Systemic
Lymphoproliferative Disorders

Figure

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  Figure 1. Contrast enhanced CT and PET-CT show generalized lymph node enlargement (black arrow). (A) chest CT. (B) abdo-men and pelvis CT. (C) PET-CT.

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  Figure 2. Enlarged cervical Lymph node shows histologically hyaline vascular type Castleman's disease. (A) A lymphoid follicle including an atrophic germinal center surrounded by a thick mantle zone consists of small lymphocytes (black arrow) (H&E stain, ×200), (B) Hyalization in the small vessels (white arrow) (H&E stain, ×100)

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  Figure 3. Immunohistochemical staining is positive for CD3, CD20, CD21, bcl2. (A) CD3 (×100), (B) CD20 (×100), (C) CD21 (×100), (D) bcl2 (×100).

Reference

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