Yonsei Med J.
2004 Dec;45(6):1053-1058. 10.3349/ymj.2004.45.6.1053.
Transplant Graft Vasculopathy: An Emerging Target for Prevention and Treatment of Renal Allograft Dysfunction
- Affiliations
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- 1Division of Nephrology, Ewha Women's University College of Medicine, Ewha Medical Research Center, Korea. dhkang@ewha.ac.kr
- 2Department of Internal Medicine (Nephrology), Yonsei University College of Medicine, Korea.
- 3Department of Pathology, Yonsei University College of Medicine, Korea.
- 4Department of Surgery (Transplantation), Yonsei University College of Medicine, Korea.
- 5Department of Medicine, The Catholic University of Korea, Seoul, Korea.
- 6Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA.
- KMID: 1726168
- DOI: http://doi.org/10.3349/ymj.2004.45.6.1053
Abstract
- Maintenance of healthy endothelium is essential to vascular homeostasis, and preservation of endothelial cell function is critical for transplant allograft function. Damage of microvascular endothelial cells is now regarded as a characteristic feature of acute vascular rejection and chronic allograft nephropathy, which is an important predictor of graft loss and is often associated with transplant vasculopathy. In this review, we will discuss the role of microvascular endothelium, in renal allograft dysfunction, particularly as it relates to markers of endothelial dysfunction and endothelial repair mechanisms. We also discuss the potential for therapies targeting endothelial dysfunction and transplant graft vasculopathy.
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