Korean J Gastroenterol.  2013 Jun;61(6):307-312. 10.4166/kjg.2013.61.6.307.

Effect of Helicobacter pylori Eradication on Subsequent Dysplasia Development after Endoscopic Resection of Gastric Dysplasia

• Chon I
• Choi C
• Shin CM
• Park YS
• Kim N
• Lee DH

• KMID: 1718061
• DOI: http://doi.org/10.4166/kjg.2013.61.6.307

Abstract

BACKGROUND/AIMS
Eradication of Helicobacter pylori reduces the incidence of gastric cancer, and may inhibit gastric dysplasia progression into gastric cancer. The aim of this study was to investigate the effect of eradication of Helicobacter on the incidence of subsequent gastric dysplasia development after endoscopic resection.
METHODS
Medical records of patients who underwent endoscopic resection for gastric dysplasia were retrospectively reviewed. Presence of H. pylori was assessed by the Campylobacter-like organism test and histology. The rate of subsequent dysplasia development after endoscopic resection between the eradication group and non-eradication group was compared.
RESULTS
Total of 129 patients positive for H. pylori infection were included for analysis. Of these, 85 patients received successful eradication therapy and 44 patients did not receive eradication therapy or failed to achieve successful eradication. Sex, mean age and pathologic grade of dysplasia did not differ between the two groups. In univariate analysis, the grade of intestinal metaplasia (p=0.013) significantly differed between metachronous dysplasia group and non-metachrounous dysplasia group. In multivariate analysis, eradication of H. pylori (p=0.014) was related to reduced incidence of subsequent gastric dysplasia development after endoscopic resection.
CONCLUSIONS
Eradication of H. pylori likely has a beneficial effect in preventing the development of subsequent gastric dysplasia, a premalignant lesion of gastric cancer, after endoscopic resection.

Keyword

Helicobacter pylori; Gastric dysplasia; Disease eradication; Endoscopic resection

MeSH Terms

Aged
Anti-Bacterial Agents/*therapeutic use
Female
Gastric Mucosa/pathology/surgery
Gastroscopy
Helicobacter Infections/*drug therapy
*Helicobacter pylori
Humans
Male
Metaplasia/pathology
Middle Aged
Neoplasm Recurrence, Local/pathology
Precancerous Conditions/*pathology
Proportional Hazards Models
Retrospective Studies
Stomach Neoplasms/pathology/*surgery
Anti-Bacterial Agents

Figure

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  Fig. 1. Patient selection criteria.

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  Fig. 2. Effect of Helicobacter pylori eradication on time to development of metachronous dysplasia.

Reference

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