J Korean Bone Joint Tumor Soc.  2014 Jun;20(1):32-35. 10.5292/jkbjts.2014.20.1.32.

Rosai-Dorfman Disease as a Solitary Lesion of the Tibia

• Kong CB
• Lee JW
• Cho SH
• Song WS
• Cho WH
• Koh JS
• Jeon DG
• Lee SY

• KMID: 1707763
• DOI: http://doi.org/10.5292/jkbjts.2014.20.1.32

Abstract

Rosai-Dorfman disease (RDD) is an idiopathic histioproliferative disorder of lymph node and extranodal site. Bone involvement is very rare. We report a case of extranodal RDD of the tibia in 32-year old male. The patient presented with pain with no evidence of lymphadenopathy. Clinico-radiologic diagnosis was metastatic carcinoma or Langerhans cell histiocytosis, but, histopathologic examination confirmed the diagnosis with RDD. We performed curettage on the osteolytic lesion of tibia. In South Korea, there was no report about RDD of the extremity and we want to report this case with review of the literature.

Keyword

Rosai-dorfman disease; bone; tibia

MeSH Terms

Curettage
Diagnosis
Extremities
Histiocytosis, Langerhans-Cell
Histiocytosis, Sinus*
Humans
Korea
Lymph Nodes
Lymphatic Diseases
Male
Tibia*

Figure

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  Figure 1. Anteroposterior view (A) & lateral view (B) of plain radiographs of left tibia show osteolytic bony lesion with endosteal scalloping.

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  Figure 2. (A) Sagittal T1-weigthed MR image of lower leg shows bony lesion with low signal intensity. (B) Coronal T2-weighted MR image shows bony lesion with low to intermediate signal intensity.

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  Figure 3. Preoperative bone scan shows increased uptake of left tibia mid-shaft. There is no abnormal uptake except left tibia.

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  Figure 4. (A) H&E staining shows large, pale histiocytes with emperiopolesis (×200). (B) Immunohistochemistry staining shows that these histiocytes are positive for S-100 protein (×200).

Reference

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