Korean J Anesthesiol.  1993 Oct;26(5):1046-1050. 10.4097/kjae.1993.26.5.1046.

A Case Report of Anaphylactoid Reaction for Thiopental

• Lim YJ
• Yang HS

• KMID: 1690064
• DOI: http://doi.org/10.4097/kjae.1993.26.5.1046

Abstract

Sodium thiopental is a popular intravenous anesthetic that has been used extensively throughout the world. The rare adverse reactions to thiopental consist mainly of anaphylactic shock, bronchospasm, and local thrombophlebitis. The reported incidence of presumed anaphylactic reaction (Type l hypersensitivity) to thiopental are extremely rare. Although the mechanism of these adverse reactiona is unclear, the clinical features (generalized erythema, hypotension, edema and bronchspasm) are thought to result from massive discharge of histamine and other vasoactive substance from basophils and mast cells. Since such reactions are life threatening, they must be recognized immediately and the appmpriate treatment given. The successful management of anaphylaxis requires a thorough understanding of this syndrome and the application of therapeutic agents. The authors report a case of anaphylactoid response to thiopental in a 34 years old healthy male patient and briefly review the literature.

Keyword

Anaphylactic reaction; thiopental sodium

MeSH Terms

Adult
Anaphylaxis
Basophils
Bronchial Spasm
Edema
Erythema
Histamine
Humans
Hypotension
Incidence
Male
Mast Cells
Sodium
Thiopental*
Thrombophlebitis
Histamine
Sodium
Thiopental