J Korean Neurol Assoc.
1992 Mar;10(1):1-7.
Diagnosis of Tuberculous Meningitis by Enzyme-Linked Immunosorbent Assay (ELISA) and Polymerase Chain Reaction (PCR) in CSF
- Affiliations
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- 1Department of Neurology, College of Medicine, Yonsei University.
- 2Department of Microbiology, College of Medicine, Yonsei University.
Abstract
- Cerebrospinal fluid from 27 patients with tuberculous meningitis and from appropriate control individuals were assayed for immunoglobulin G activity to tuberculin purified protein derivative (PPD) and Lipoarabinomannan-B (LAM-B) antigens by a'n enzyme-linked immunosorbent assay (ELISA), and polymerase chain reaction (PCR). A significant difference was found between the tuberculous meningitis group and control. The sensitivity and specificity of these tests in cerebrospinal fluid was 59.2% and 93.9% for PPD, 85.2% and 95.9% for LAM-B antigen, and 70.3% and 89.7% for PCR method. The ELISA method measuring IgG antibody to LAM-B in cerebrospinal fluid and PCR method were both reliable and complementary each other for early diagnosis of patient with tuberculous meningitis.
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