Korean Circ J.  1973 Jun;3(1):1-7. 10.4070/kcj.1973.3.1.1.

Effects of Acute Carbon Monoxide Poisoning on Hepatic Blood Flow


The effects of acute carbon monoxide poisoning on the hepatic blood flow were studied in mongrel dogs. In this study dogs were divided into two groups, namely control and experimental, and the hepatic blood flow measured by the determination of the fractional clearance of the intravenously administered colloid 198Au. In the experimental group carbon monoxide poisoning was induced by the rebreathing of about 2% CO gas mixture for 15 minutes, and the hepatic blood flow was measured before and 30 minutes after the completion of the rebreathing of the gas mixture. The hepatic blood flow in the experimental group showed a insignificant relative increase compared to that in the control group. The alteration of the mean value of the hepatic blood flow following carbon monoxide poisoning appeared proportionate to that of the cardiac index, and inversely proportionate to those of the femoral artery mean pressure and the total peripheral resistance. However, the individual value of hepatic blood flow revealed no correlation with any of these hemodynamic measurements.

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