Korean J Gastrointest Endosc.  2005 Oct;31(4):278-281.

A Case of Hepatocellular Carcinoma Invading Intrahepatic Duct Complicated by Hemobilia

  • 1Department of Internal Medicine and Liver Research Institute, Korea. hsleemd@snu.ac.kr
  • 2Department of Pathology Seoul National University College of Medicine, Seoul, Korea.


A seventyone-year-old male presented with sudden epigastric pain followed by jaundice and intermittent right upper abdominal pain. He was diagnosed as hepatocellular carcinoma 7 years ago, and has been treated with transarterial chemoembolization, percuaneous ethanol injection and segmentectomy. On admission, the level of serum bilirubin, amylase and lipase were 8.7 mg/dL, 560 IU/L, and 13,297 IU/L, respectively. Stool occult blood test was positive. Abdominal computed tomography revealed newly-appeared intraductal soft tissue mass with ductal dilatation. Endoscopic retrograde cholangiography demonstrated filling defects in the common hepatic and distal common bile duct (CBD). Endoscopic sphincterotomy was performed and the clots in the distal CBD were removed. An intraductal stent was inserted at the common hepatic duct. The obstructive jaundice and pancreatitis were resolved. Our case suggests that intraductal hepatocellular carcinoma may induce hemobilia as a possible cause of acute pancreatitis.


Hepatocellular carcinoma; Hemobilia; Acute pancreatitis
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