J Korean Pediatr Soc.  1998 Jul;41(7):994-1000.

The Lymphocyte Subset Change in a Case of Subacute Necrotizing Lymphadenitis

• Doh JH
• Kim ST
• Lee KS
• Jeong SY

Abstract

The subacute necrotizing lymphadenitis, also known as Kikuchi-Fujimoto disease, is a benign, self-limited disorder of unknown cause. This rare disease is characterized by fever, lymphadenopathy, leukopenia, and elevated sedimentation rate. This disease preferentially affects young women. The diagnosis of this disease is confirmed by involved lymphnodes biopsy. Evidence for autoimmune dysfunction has been reported, but is usually lacking. According to the review of the literatures, a total of 192 cases of subacute necrotizing lymphadenitis were reported in Korea since 1983 mostly in literatures of pathology or internal medicine and only 7 cases in pediatrics. There was female predominance in a 141:51 ratio. However, among 25 cases of under 20 years of age, there was male predominance in a 16:9 ratio. The patients of under and over 20 years of age were 29 and 82, respectively among the age-known 111 cases of 192 reported. We experienced a 13-year-old boy, who had right cervical lymphadenitis with persisting high temperature and pain on lymph nodes for more than 10 days. An excisional cervical lymph node biopsy was performed and pathologic diagnosis was compatible with subacute necrotizing lymphadenitis. Most antibiotics were not effective, but fever subsided with one day of oral prednisolone therapy. Various laboratory studies for prolonged fever were negative except leukopenia and increased sedimentation rates. The CD4/CD8 ratios in acute and recovery stages were 1.1 and 1.5 respectively, showing mild decrease of CD4/CD8 ratio in the acute stage. Decreased T cell proportions in the acute stage were also noted.

Keyword

Lymphocyte Subset; Subacute necrotizing lymphadenitis

MeSH Terms

Adolescent
Anti-Bacterial Agents
Biopsy
Diagnosis
Female
Fever
Histiocytic Necrotizing Lymphadenitis
Humans
Internal Medicine
Korea
Leukopenia
Lymph Nodes
Lymphadenitis*
Lymphatic Diseases
Lymphocyte Subsets*
Lymphocytes*
Male
Pathology
Pediatrics
Prednisolone
Rare Diseases
Anti-Bacterial Agents
Prednisolone