Korean J Anat.  2001 Dec;34(6):567-578.

Changes of Ultrastructure and Atrial Specific Granules of Atrial Myocytes in Dehydrated and Rehydrated Rats

• Kim HT
• Kim H
• Song CH
• Han EH
• Lee MS

Abstract

The ultrastructural changes of atrial myocytes were examined by transmission electron microscopy and ultrastructural morphometry by dehydrated and rehydrated rat. Sprague-Dawley rats weighting 210 to 240 gm were fed with dried diet and without water for 3, 7 and 9 days, and then with standard diet and tap water for 9 days. On day 7 of dehydration, morphological changes in atrial myocytes were mainly the alterations of mitochondria and myofibrils, and the appearance of vacuoles with myelin structures and vesicular typed granules. On day 9 of dehydration, cells containing the myelin structures were increased than those on day 7 of dehydration. On day 3 to 5 rehydration, many atrial myocytes were damaged. On day 9 rehydration, most atrial myocytes were similar to control groups. The numbers of atrial specific granules were increased in all dehydrated groups and decreased in 1 day and 3 day rehydrated groups then that of normal atria. The numbers of atrial specific granules were similar level to normal animals in 5 day and 9 day rehydrated groups.

Keyword

Atrium; Dehydration; Rehydration; Specific granule; Ultrastructure

MeSH Terms

Animals
Dehydration
Diet
Fluid Therapy
Microscopy, Electron, Transmission
Mitochondria
Muscle Cells*
Myelin Sheath
Myofibrils
Rats*
Rats, Sprague-Dawley
Vacuoles
Water
Water