Korean J Infect Dis.
1997 Sep;29(5):423-426.
The Growth of Staphylococcus aureus in Intravenous Anesthetics
- Affiliations
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- 1Department of Anesthesiology, College of Medicine, Kyung Hee University, Seoul, Korea.
- 2Department of Clinical Pathology, College of Medicine, Kyung Hee University, Seoul, Korea.
Abstract
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BACKGROUND: Patients infected with Staphylococcus aureus related to the use of propofol have been reported. The purpose of this study was to assess and compare the growth of S. aureus in propofol, thiopental, midazolam and ketamine.
METHODS
These intravenous anesthetics were inoculated with S. aureus and they were plated onto blood agar at 0, 3, 6, 21, 24 and 27 hrs. The number of colony forming units (CFU) on the plate was counted after 24 hours of incubation.
RESULTS
Samples from ketamine and midazolam showed no CFU at the 3 hr and thereafter. The 21hr, thiopental exhibited no CFU. The inoculated propofol emulsion showed a significant increase in number of CFU at the 21, 24 and 27hr compared with the zero time (P<0.05).
CONCLUSIONS
This study shown that propofol was the only anesthetic that provided a medium for the growth of S. aureus. Therefore when handling propofol, meticulous sterile technique is advised.
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