J Korean Soc Magn Reson Med.
1997 Dec;1(1):125-129.
Correlation Between the Expression of Epidermal Growth Factor Receptor and MR Features in Glioma
Abstract
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PURPOSE: The aim of this study was to find correlation between the expression of epidermal growth factor receptor (ECFR) and MR findings in the brain glioma.
MATERIALS AND METHODS
MR features including edema, margin, necrosis, heterogeneity, hemorrhage and contrast enhancement were retrospectively analyzed with preoperative MR images in 41 patients with proven brain gliomas (8 low grade astrocytomas, 12 anaplastic astrocytomas, 21 glioblastoma multiformes). Immunohistochemical study of EGFR was done and their expressions were graded by both stained distribution and intensity. Correlation analysis between the MR features and EGFR expressions was done.
RESULTS
Peritumoral edema was correlated with both distribution (r=0.71, p=0.00) and stain intensity (r=0.69, p=0.00) of EGFR expression. Other MR features showed no statistical correlation with EGFR expression.
CONCLUSION
MRI is useful in evaluation of brain glioma, and peritumoral edema is useful findings that suggests EGFR expression as well as malignant histopathologic grade of the tumor.
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