Hanyang Med Rev.  2007 Aug;27(3):41-50.

Extragastric diseases associated with Helicobacter pylori infection

  • 1Division of Gastroenterology, Department of Internal Medicine, Eulji General Hospital, Eulji University College of Medicine, Korea. jyj1138@eulji.ac.kr


Helicobacter pylori infection is the main cause of chronic atrophic gastritis, peptic ulcer disease, gastric carcinoma, and mucosal associated lymphoid tumor. Recently, Helicobacter pylori infection has been reported in the association with several extragastric diseases such as idiopathic thrombocytopenic purpura (ITP), iron deficiency anemia (IDA), cardiovascular disease, respiratory disease, autoimmune disease, chronic urticaria and growth retardation, but the evidence of data has not been complete and is not widely known. According to up-to-date ideas, H. pylori eradication should be treated in the case of ITP and IDA. Here, we reviewed the extragastric diseases presumpted with the association of Helicobacter pylori infection, but the evidences need further investigation.


Helicobacter pylori; Extragastric disease; Idiopathic thrombocytopenic purpura; Iron deficiency anemia; Cardiovascular disease

MeSH Terms

Anemia, Iron-Deficiency
Autoimmune Diseases
Cardiovascular Diseases
Chronic Disease
Gastritis, Atrophic
Helicobacter pylori*
Peptic Ulcer
Purpura, Thrombocytopenic, Idiopathic
Stomach Diseases
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