Korean J Pathol.  2007 Aug;41(4):258-262.

Nasal Chondromesenchymal Hamartoma: A Case Report

  • 1Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. thanksg@uuh.ulsan.kr
  • 2Department of Pathology, University of Sungkyunkwan School of Medicine, Samsung Medical Center, Seoul, Korea.
  • 3Department of Pathology, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea.


We report a case of nasal chondromesenchymal hamartoma. A 14-year-old boy presented with a 5 cm sized mass in the left maxillary sinus, facial swelling and a loose tooth. A subtotal left maxillectomy with a bone graft was performed. The excised mass was composed of partly encapsulated, solid and cystic fragments of soft tissues. The mass contained chondroid and myxoid areas consisting of mesenchymal tissues including hyaline cartilage, osteoid and spindle cells in various proportions. The hyaline cartilage component was the most prominent. The spindle cell component had a fibrous matrix with variable myxoid or sclerotic changes. Thick hyalinized eosinophilic osteoid-like trabeculae were focally present. Immunohistochemically, all the mesenchymal cells tested positive for vimentin. The chondrocytes tested positive for the S-100 protein, and the spindle cell component showed focal immunoreactivity for smooth muscle actin and desmin. However, the cells were negative to pan-cytokeratin and p63.


Nose neoplasm; Hamartoma; Adolescent; Aneurysmal bone cyst; Immunohistochemistry
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